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Two-dimensional silicene composite nanosheets enable exogenous/endogenous-responsive and synergistic hyperthermia-augmented catalytic tumor theranostics
Duan, HC; Guo, HY; Zhang, RF; Wang, FF; Liu, Z; Ge, M; Yu, LD; Lin, H; Chen, Y
2020-10-01
Source PublicationBIOMATERIALS
ISSN0142-9612
SubtypeArticle
AbstractSilicene as an emerging two-dimensional material (2DM) spurs the broad research interests due to its prominent electronic and physical properties, however, still lacking in exploitation for the biological and medical practices. Herein, we constructed a 2D silicene-based theranostic nanoplatform, MnOx@silicene-BSA (MS-BSA), with tumor microenvironment (TME)-responsive and synergistic hyperthermia-augmented catalytic activity when irradiated by near infrared-II (NIR-II) laser because of the high photothermal-conversion efficiency of 2D silicene matrix. Such MS-BSA nanosheets possess the capability to react with glutathione (GSH) to generate Mn2+ and glutathione disulfide (GSSG) under acidity/reducing TME condition. With the presence/assistance of HCO3-, the released Mn2+ exhibited sensitive catalytic activity towards endogenous H2O2 via Fenton-like reaction, enabling the generation of highly toxic hydroxyl radicals (center dot OH), which finally led to the enhanced nanocatalytic therapeutic efficacy followed by exogenous NIR-II laser exposure, originating from hyperthermia-augmented catalytic activity. Especially, these MS-BSA nanosheets accumulated into the tumor region to enable superb contrast enhancement of TME-responsive T-1-weighted magnetic resonance imaging (MRI) and photoacoustic imaging (PAI), and high-efficient in vivo synergistic tumor eradication. Therefore, such an intelligent photothermal-enhanced catalytic theranostic nanoplatform could realize the exogenous/endogenous-responsive and cooperative hyperthermia-augmented tumor treatment and accurate tumor positioning/monitoring.
DOI10.1016/j.biomaterials.2020.120206
WOS KeywordBLACK PHOSPHORUS NANOSHEETS ; PHOTOTHERMAL THERAPY ; IN-VIVO ; GRAPHENE ; GLUTATHIONE ; NANOCARRIERS ; GENERATION ; APOPTOSIS
Language英语
WOS Research AreaEngineering ; Materials Science
PublisherELSEVIER SCI LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27722
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Duan, HC,Guo, HY,Zhang, RF,et al. Two-dimensional silicene composite nanosheets enable exogenous/endogenous-responsive and synergistic hyperthermia-augmented catalytic tumor theranostics[J]. BIOMATERIALS,2020.
APA Duan, HC.,Guo, HY.,Zhang, RF.,Wang, FF.,Liu, Z.,...&Chen, Y.(2020).Two-dimensional silicene composite nanosheets enable exogenous/endogenous-responsive and synergistic hyperthermia-augmented catalytic tumor theranostics.BIOMATERIALS.
MLA Duan, HC,et al."Two-dimensional silicene composite nanosheets enable exogenous/endogenous-responsive and synergistic hyperthermia-augmented catalytic tumor theranostics".BIOMATERIALS (2020).
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