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Multifaceted application of nanoparticle-based labeling strategies for stem cell therapy
Ma, M; Shu, YM; Tang, YH; Chen, HR
2020-10-01
Source PublicationNANO TODAY
ISSN1748-0132
SubtypeReview
AbstractStem cell therapy can overcome many unmet clinical challenges that have proven intractable with traditional medicine and treatment strategies because of their strong ability to recover and regenerate injured tissue. Nanoparticle-based labeling agents, in combination with current imaging technologies, have been used to monitor the location, migration, survival, and differentiation of transplanted stem cells in therapeutic processes to fully understand their fates in vivo. In addition, various kinds of functional nanoparticles can exert unique biological effects on stem cells to overcome some problems of current stem cell therapy involving cell homing, survival, retention, and directional differentiation. Moreover, nanoparticle-based theranostic labeling, in which both imaging and treatment modalities are delivered with the stem cells, has emerged as a new strategy to enhance the therapeutic effect of stem cells and shows great potential for future stem cell therapy. The aim of this review is to describe the current roles played by nanoparticles in cell tracking, cell fate regulation, and theranostic labeling in stem cell therapy. Important issues and perspectives on the potential growth of this area are also critically discussed. (C) 2020 Elsevier Ltd. All rights reserved.
DOI10.1016/j.nantod.2020.100897
WOS KeywordMESOPOROUS SILICA NANOPARTICLES ; IRON-OXIDE NANOPARTICLES ; MRI CONTRAST AGENTS ; PROMOTE OSTEOGENIC DIFFERENTIATION ; AGGREGATION-INDUCED EMISSION ; LONG-TERM TRACKING ; IN-VIVO ; SILVER NANOPARTICLES ; GOLD NANOPARTICLES ; QUANTUM DOTS
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27708
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Ma, M,Shu, YM,Tang, YH,et al. Multifaceted application of nanoparticle-based labeling strategies for stem cell therapy[J]. NANO TODAY,2020.
APA Ma, M,Shu, YM,Tang, YH,&Chen, HR.(2020).Multifaceted application of nanoparticle-based labeling strategies for stem cell therapy.NANO TODAY.
MLA Ma, M,et al."Multifaceted application of nanoparticle-based labeling strategies for stem cell therapy".NANO TODAY (2020).
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