SIC OpenIR
A cation exchange strategy to construct a targeting nanoprobe for enhanced T-1-weighted MR imaging of tumors
Chen, SY; Zhang, Q; Sun, HT; Zheng, YY; Chen, Q; Luo, Y; Chen, HR; Zhou, Q
2020-10-07
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Issue37Pages:8519
SubtypeArticle
AbstractExcellent imaging performance and good biocompatibility of contrast agents are considered as prerequisites for accurate tumor diagnosis. In this study, a novel imaging nanoprobe with actively targeting performance based on ultrasmall paramagnetic iron oxide (USPIO) nanoparticles was constructed by a facile cation exchange strategy followed by conjugation with transferrin (Tf). The stable gadolinium (Gd3+) chelation endows the nanoparticles (NPs) with a low value of r(2)/r(1) (1.28) and a relatively high r(1) value of 3.2 mM(-1) s(-1), enabling their use for T-1-weighted positive magnetic resonance (MR) imaging. This constructed transferrin modified gadolinium-iron chelate nanoprobe, named as TUG, shows high biocompatibility within a given dose range. More importantly, compared with clinically used Gd-based small molecule contrast agents, the obtained TUG can be more engulfed by breast cancer cells, showing much enhanced T-1-weighted positive MR imaging in both subcutaneous and orthotopic tumor models of breast cancer. This novel nanoprobe holds great promise to be utilized as a targeting contrast agent with high efficacy for T-1-weighted positive MR imaging.
DOI10.1039/d0tb01632b
WOS KeywordIRON-OXIDE NANOPARTICLES ; CONTRAST AGENTS ; RELAXIVITY
Language英语
WOS Research AreaMaterials Science
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27703
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Chen, SY,Zhang, Q,Sun, HT,et al. A cation exchange strategy to construct a targeting nanoprobe for enhanced T-1-weighted MR imaging of tumors[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020(37):8519.
APA Chen, SY.,Zhang, Q.,Sun, HT.,Zheng, YY.,Chen, Q.,...&Zhou, Q.(2020).A cation exchange strategy to construct a targeting nanoprobe for enhanced T-1-weighted MR imaging of tumors.JOURNAL OF MATERIALS CHEMISTRY B(37),8519.
MLA Chen, SY,et al."A cation exchange strategy to construct a targeting nanoprobe for enhanced T-1-weighted MR imaging of tumors".JOURNAL OF MATERIALS CHEMISTRY B .37(2020):8519.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Chen, SY]'s Articles
[Zhang, Q]'s Articles
[Sun, HT]'s Articles
Baidu academic
Similar articles in Baidu academic
[Chen, SY]'s Articles
[Zhang, Q]'s Articles
[Sun, HT]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Chen, SY]'s Articles
[Zhang, Q]'s Articles
[Sun, HT]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.