KMS Shanghai Institute of Ceramics，Chinese Academy of Sciences
| Microfluidics-Assisted Surface Trifunctionalization of a Zeolitic Imidazolate Framework Nanocarrier for Targeted and Controllable Multitherapies of Tumors | |
| Shen, J; Ma, M; Zhang, HB; Yu, HZ; Xue, FF; Hao, NJ; Chen, HR | |
| 2020-10-14 | |
| Source Publication | ACS APPLIED MATERIALS & INTERFACES
 |
| ISSN | 1944-8244 |
| Issue | 41Pages:45838 |
| Subtype | Article |
| Abstract | Metal-organic framework (MOP)-based drug delivery nanosystems with both precise drug release and multidrug codelivery capabilities have emerged as promising candidates for cancer treatment. However, challenges are posed by the limited number of suitable payload types, uncontrollable drug leakage, and lack of chemical groups for postmodification. To overcome those challenges, we developed a core-shell nanocomposite composed of zeolitic imidazolate framework-90 (ZIF-90) coated with spermine-modified acetalated dextran (SAD) by a facile microfluidics-based nanoprecipitation method. This nanocomposite could serve as a multidrug storage reservoir for the loading of two drugs with distinct properties, where the hydrophilic doxorubicin (DOX) was coordinately attached to the ZIF-90 framework, and hydrophobic photosensitizer IR780 was loaded into the SAD shell, enabling the combination therapy of photodynamic treatment with chemotherapy. Meanwhile, equipping ZIF-90 with a SAD shell not only substantially improved the pH-responsive drug release of ZIF-90 but also enabled the postformation conjugation of ZIF-90 with hyaluronic acid for specific CD44 recognition, thereby facilitating precise drug delivery to CD44-overexpressed tumor. Such a simple microfluidics-based strategy can efficiently overcome the limitations of solely MOF-based DDSs and greatly extend the flexibility of MOP biomedical applications. |
| DOI | 10.1021/acsami.0c14021 |
| WOS Keyword | DRUG-DELIVERY SYSTEMS ; SHELL NANOPARTICLES ; THERAPY ; RELEASE ; ZIF-90 |
| Language | 英语 |
| WOS Research Area | Science & Technology - Other Topics ; Materials Science |
| Publisher | AMER CHEMICAL SOC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sic.ac.cn/handle/331005/27688 |
| Collection | 中国科学院上海硅酸盐研究所 |
| Recommended Citation GB/T 7714 | Shen, J,Ma, M,Zhang, HB,et al. Microfluidics-Assisted Surface Trifunctionalization of a Zeolitic Imidazolate Framework Nanocarrier for Targeted and Controllable Multitherapies of Tumors[J]. ACS APPLIED MATERIALS & INTERFACES,2020(41):45838. |
| APA | Shen, J.,Ma, M.,Zhang, HB.,Yu, HZ.,Xue, FF.,...&Chen, HR.(2020).Microfluidics-Assisted Surface Trifunctionalization of a Zeolitic Imidazolate Framework Nanocarrier for Targeted and Controllable Multitherapies of Tumors.ACS APPLIED MATERIALS & INTERFACES(41),45838. |
| MLA | Shen, J,et al."Microfluidics-Assisted Surface Trifunctionalization of a Zeolitic Imidazolate Framework Nanocarrier for Targeted and Controllable Multitherapies of Tumors".ACS APPLIED MATERIALS & INTERFACES .41(2020):45838. |
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