KMS Shanghai Institute of Ceramics，Chinese Academy of Sciences
| Bioglass/Polylactic Acid Porous Microspheres: Preparation and Their Application as Cell Microcarriers | |
| Gao, L; Zhang, ZWB; Chang, J | |
| 2020-10-20 | |
| Source Publication | JOURNAL OF INORGANIC MATERIALS
 |
| ISSN | 1000-324X |
| Issue | 10Pages:1163 |
| Subtype | Article |
| Abstract | Porous microsphere cell microcarrier with macroporous structure cannot only amplify cells in vitro, but also serve as cell delivery tools to deliver cells to damaged tissues by injection. Bioglass (BG) is an inorganic material with excellent biological activity, however, it is difficult to directly prepare microcarriers with macroporous structure. Therefore, in this study, a BG/poly-lactic acid (PLA) porous microspheres was prepared by double emulsion method. The morphology and structure of the microsphere were characterized by SEM, and the load of BG in the microsphere was characterized by thermo gravimetric analysis and its ion release was detected by ICP. Cell proliferation experiments showed that cells could adhere and grow on the surface and inside of the microspheres. The results show that the microsphere with interconnected open-pore microstructure is suit for cell adhesion and proliferation. Bioglass can promote cell proliferation in the microspheres and the obtained BG/PLA composite microsphere has great potential applications in tissue engineering. |
| DOI | 10.15541/jim20190593 |
| WOS Keyword | MESENCHYMAL STEM-CELLS ; BONE REGENERATION ; CARTILAGE ; EXPANSION ; BEADS |
| Language | 中文 |
| WOS Research Area | Materials Science |
| Publisher | SCIENCE PRESS |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sic.ac.cn/handle/331005/27677 |
| Collection | 中国科学院上海硅酸盐研究所 |
| Recommended Citation GB/T 7714 | Gao, L,Zhang, ZWB,Chang, J. Bioglass/Polylactic Acid Porous Microspheres: Preparation and Their Application as Cell Microcarriers[J]. JOURNAL OF INORGANIC MATERIALS,2020(10):1163. |
| APA | Gao, L,Zhang, ZWB,&Chang, J.(2020).Bioglass/Polylactic Acid Porous Microspheres: Preparation and Their Application as Cell Microcarriers.JOURNAL OF INORGANIC MATERIALS(10),1163. |
| MLA | Gao, L,et al."Bioglass/Polylactic Acid Porous Microspheres: Preparation and Their Application as Cell Microcarriers".JOURNAL OF INORGANIC MATERIALS .10(2020):1163. |
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