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Bioglass/Polylactic Acid Porous Microspheres: Preparation and Their Application as Cell Microcarriers
Gao, L; Zhang, ZWB; Chang, J
2020-10-20
Source PublicationJOURNAL OF INORGANIC MATERIALS
ISSN1000-324X
Issue10Pages:1163
SubtypeArticle
AbstractPorous microsphere cell microcarrier with macroporous structure cannot only amplify cells in vitro, but also serve as cell delivery tools to deliver cells to damaged tissues by injection. Bioglass (BG) is an inorganic material with excellent biological activity, however, it is difficult to directly prepare microcarriers with macroporous structure. Therefore, in this study, a BG/poly-lactic acid (PLA) porous microspheres was prepared by double emulsion method. The morphology and structure of the microsphere were characterized by SEM, and the load of BG in the microsphere was characterized by thermo gravimetric analysis and its ion release was detected by ICP. Cell proliferation experiments showed that cells could adhere and grow on the surface and inside of the microspheres. The results show that the microsphere with interconnected open-pore microstructure is suit for cell adhesion and proliferation. Bioglass can promote cell proliferation in the microspheres and the obtained BG/PLA composite microsphere has great potential applications in tissue engineering.
DOI10.15541/jim20190593
WOS KeywordMESENCHYMAL STEM-CELLS ; BONE REGENERATION ; CARTILAGE ; EXPANSION ; BEADS
Language中文
WOS Research AreaMaterials Science
PublisherSCIENCE PRESS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27677
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Gao, L,Zhang, ZWB,Chang, J. Bioglass/Polylactic Acid Porous Microspheres: Preparation and Their Application as Cell Microcarriers[J]. JOURNAL OF INORGANIC MATERIALS,2020(10):1163.
APA Gao, L,Zhang, ZWB,&Chang, J.(2020).Bioglass/Polylactic Acid Porous Microspheres: Preparation and Their Application as Cell Microcarriers.JOURNAL OF INORGANIC MATERIALS(10),1163.
MLA Gao, L,et al."Bioglass/Polylactic Acid Porous Microspheres: Preparation and Their Application as Cell Microcarriers".JOURNAL OF INORGANIC MATERIALS .10(2020):1163.
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