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Black Bioceramics: Combining Regeneration with Therapy
Wang, XC; Xue, JM; Ma, B; Wu, JF; Chang, J; Gelinsky, M; Wu, CT
2020-12-01
Source PublicationADVANCED MATERIALS
ISSN0935-9648
Issue48
SubtypeArticle
AbstractBioceramics have been developed from bioinert to bioactive or biodegradable materials in the past few decades. However, at present, traditional bioceramics are still mainly used in bone tissue regeneration and dental restoration. In this work, a new generation of "black bioceramics," extending the applications from tissue regeneration to disease therapy, is presented. Black bioceramics, through magnesium thermal reduction of traditional white ceramics, including silicate-based (e.g., CaSiO3, MgSiO3) and phosphate-based (e.g., Ca-3(PO4)(2), Ca-5(PO4)(3)(OH)), are successfully synthesized. Due to the presence of oxygen vacancies and structural defects, the black bioceramics possess photothermal functionality while maintaining their initial high bioactivity and regenerative capacity. These black bioceramics show excellent photothermal antitumor effects for both skin and bone tumors. At the same time, they have significantly improved bioactivity for skin/bone tissue repair in vitro and in vivo. These fascinating properties award the black bioceramics with profound applications in both tumor therapy and tissue regeneration, which should greatly promote the scientific relevance and clinical application of bioceramics, representing a promising new direction of cell-instructive biomaterials.
DOI10.1002/adma.202005140
WOS KeywordTUMOR-THERAPY ; BONE REGENERATION ; ANGIOGENESIS ; STIMULATION ; BIOMATERIAL ; FIBROBLAST ; NANOSHEETS ; SCAFFOLDS ; CELLS ; STATE
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27670
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Wang, XC,Xue, JM,Ma, B,et al. Black Bioceramics: Combining Regeneration with Therapy[J]. ADVANCED MATERIALS,2020(48).
APA Wang, XC.,Xue, JM.,Ma, B.,Wu, JF.,Chang, J.,...&Wu, CT.(2020).Black Bioceramics: Combining Regeneration with Therapy.ADVANCED MATERIALS(48).
MLA Wang, XC,et al."Black Bioceramics: Combining Regeneration with Therapy".ADVANCED MATERIALS .48(2020).
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