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Zanthoxylum nitidum extract attenuates BMP-2-induced inflammation and hyperpermeability
Hu, T; Luo, ZW; Li, K; Wang, SJ; Wu, DS
2020-10-23
Source PublicationBIOSCIENCE REPORTS
ISSN0144-8463
SubtypeArticle
AbstractBone morphogenetic protein-2 (BMP-2) is commonly applied in spinal surgery to augment spinal fusion. Nevertheless, its pro-inflammatory potential could induce dangerous side effects such as vascular hyper-permeability, posing the need for manners against this condition. The present study aims to investigate the protective effect of Zanthoxylum nitidum (ZN) on BMP-2-related hyperpermeability and inflammation on the human umbilical vein endothelial cells (HUVECs). The results revealed that, in a concentration-dependent manner, BMP-2 enhanced the production of pro-inflammatory cytokines, including interleukin (IL)-1 alpha, IL-1 beta, and tumor necrosis factor-alpha, which were, however, suppressed by ZN. ZN inhibited BMP-2-induced inflammatory response by suppressing the phosphorylation of NF-kappa Bp65 and I kappa B, and the abnormal nuclear translocation of p65. Moreover, the inhibited expression intercellular tight junction protein VE-cadherin and Occludin caused by BMP-2 was blocked by ZN. The hyper-permeability of HUVECs induced by BMP-2, as expressed as the higher fluorescent intensity of dextran, was also reversed by ZN. Overall, these findings demonstrated that ZN antagonized BMP-2-induced inflammation and hyperpermeability. It could be a therapeutic candidate for the treatment of BMP-2-induced side effects during spinal fusion.
DOI10.1042/BSR20201098
WOS KeywordBONE MORPHOGENETIC PROTEIN-2 ; BENZOPHENANTHRIDINE ALKALOIDS ; SIGNALING PATHWAY ; FUSION ; CELLS ; RHBMP-2 ; ROOTS
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
PublisherPORTLAND PRESS LTD
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Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27669
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Hu, T,Luo, ZW,Li, K,et al. Zanthoxylum nitidum extract attenuates BMP-2-induced inflammation and hyperpermeability[J]. BIOSCIENCE REPORTS,2020.
APA Hu, T,Luo, ZW,Li, K,Wang, SJ,&Wu, DS.(2020).Zanthoxylum nitidum extract attenuates BMP-2-induced inflammation and hyperpermeability.BIOSCIENCE REPORTS.
MLA Hu, T,et al."Zanthoxylum nitidum extract attenuates BMP-2-induced inflammation and hyperpermeability".BIOSCIENCE REPORTS (2020).
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