SIC OpenIR
Highly dispersed nano-enzyme triggered intracellular catalytic reaction toward cancer specific therapy
Mei, X; Hu, TT; Wang, H; Liang, RZ; Bu, WB; Wei, M
2020-11-01
Source PublicationBIOMATERIALS
ISSN0142-9612
SubtypeArticle
AbstractCurrently, reactive oxygen species (ROS)-induced apoptosis systems have drawn increasing attention in cancer therapy, owing to their specific tumor inhibition ability and great biocompatibility. Herein, we developed a highly dispersed nano-enzyme based on the assembly of natural glucose oxidase (GOD) onto CoFe-layered double hydroxides (CoFe-LDHs) monolayer nanosheets. By virtue of the high dispersion of Fe3+ within the host layer, the CoFe-LDHs nanosheets exhibit a collaborative enhanced Fenton catalytic activity with a rate constant of 3.26 x 10(-4) s-(1) , which is 1-3 orders of magnitude higher than other iron-containing Fenton reaction agents. Subsequently, with a massive H2O2 triggered by GOD, GOD/CoFe-LDHs nanohybrid converts a cascade of glucose into hydroxyl radicals under tumor acid conditions, which is validated by a high maximum velocity (V-max = 2.23 x 10(-6) M) and low Michaelis-Menten constant (K-M = 5.40 mM). Through the intracellular catalytic Fenton reaction within the tumor environment, both in vitro and in vivo results demonstrate the excellent antitumor effect of GOD/CoFe-LDHs. Therefore, a self-supplied, ultra-efficient and sequential catalytic tumor-specific therapy has been achieved based on GOD/CoFe-LDHs nano-enzyme, which holds great promise in clinical cancer therapy with minimum side effects.
DOI10.1016/j.biomaterials.2020.120257
WOS KeywordLAYERED DOUBLE HYDROXIDE ; FENTON REACTION ; TUMOR ; DNA ; NANOPARTICLES ; DELIVERY ; RESONANCE ; WATER ; MRI
Language英语
WOS Research AreaEngineering ; Materials Science
PublisherELSEVIER SCI LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27659
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Mei, X,Hu, TT,Wang, H,et al. Highly dispersed nano-enzyme triggered intracellular catalytic reaction toward cancer specific therapy[J]. BIOMATERIALS,2020.
APA Mei, X,Hu, TT,Wang, H,Liang, RZ,Bu, WB,&Wei, M.(2020).Highly dispersed nano-enzyme triggered intracellular catalytic reaction toward cancer specific therapy.BIOMATERIALS.
MLA Mei, X,et al."Highly dispersed nano-enzyme triggered intracellular catalytic reaction toward cancer specific therapy".BIOMATERIALS (2020).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Mei, X]'s Articles
[Hu, TT]'s Articles
[Wang, H]'s Articles
Baidu academic
Similar articles in Baidu academic
[Mei, X]'s Articles
[Hu, TT]'s Articles
[Wang, H]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Mei, X]'s Articles
[Hu, TT]'s Articles
[Wang, H]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.