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Photothermo-Promoted Nanocatalysis Combined with H2S-Mediated Respiration Inhibition for Efficient Cancer Therapy
Yang, ZB; Luo, Y; Hu, YA; Liang, KC; He, G; Chen, Q; Wang, QG; Chen, HR
2020-11-07
Source PublicationADVANCED FUNCTIONAL MATERIALS
ISSN1616-301X
SubtypeArticle; Early Access
AbstractNanocatalytic medicine has emerged as a promising method for the specific cancer therapy by mediating the interaction between tumor microenvironment biomarkers and nanoagents. However, the produced antitumor cell killing molecules, such as reactive oxygen species (ROS), by catalysis are insufficient to inhibit tumor growth. Herein, a novel kind of polyvinyl pyrrolidone modified multifunctional iron sulfide nanoparticles (Fe1-xS-PVP NPs) is developed via a one-step hydrothermal method, which exhibits high photothermal (PT) conversion efficiency (eta = 24%) under the irradiation of 808 nm near-infrared laser. The increased temperature further facilitates the Fenton reaction to generate abundant center dot OH radicals. More importantly, under an acidic (pH = 6.5) condition within tumor environment, the Fe1-xS-PVP NPs can in situ produce H2S gas, which is evidenced to suppress the activity of enzyme cytochrome c oxidase (COX IV) in cancer cells, contributing to inhibit the growth of tumor. Both in vitro and in vivo results demonstrate that the H2S-mediated gas therapy in combination with PT enhanced ROS achieves excellent antitumor performance, which can open up a new approach for the design of gas-mediated cancer treatment.
DOI10.1002/adfm.202007991
WOS KeywordCYTOCHROME-C-OXIDASE ; HYDROGEN-SULFIDE ; TUMOR HYPOXIA ; NANOPARTICLES ; NANOCRYSTALS ; MITOCHONDRIA
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27635
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Yang, ZB,Luo, Y,Hu, YA,et al. Photothermo-Promoted Nanocatalysis Combined with H2S-Mediated Respiration Inhibition for Efficient Cancer Therapy[J]. ADVANCED FUNCTIONAL MATERIALS,2020.
APA Yang, ZB.,Luo, Y.,Hu, YA.,Liang, KC.,He, G.,...&Chen, HR.(2020).Photothermo-Promoted Nanocatalysis Combined with H2S-Mediated Respiration Inhibition for Efficient Cancer Therapy.ADVANCED FUNCTIONAL MATERIALS.
MLA Yang, ZB,et al."Photothermo-Promoted Nanocatalysis Combined with H2S-Mediated Respiration Inhibition for Efficient Cancer Therapy".ADVANCED FUNCTIONAL MATERIALS (2020).
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