SIC OpenIR
Injectable Magnetic Liquid-solid Phase Transition Material for MR Imaging and Low-temperature Magnetocaloric Therapy of Osteosarcoma
Xu, D; Zhu, YF; Zheng, YY; Luo, Y; Chen, HR
2020-11-20
Source PublicationJOURNAL OF INORGANIC MATERIALS
ISSN1000-324X
Issue11Pages:1277
SubtypeArticle
AbstractOverhigh temperature can induce inflammation and heat radiation damage to normal tissues around the tumor. Therefore, the development of a magnetic material that can achieve high mortality of tumor cells at relatively low temperatures (e.g. 43 degrees C) is critical for the clinical application of magnetocaloric therapy. This study focuses on the goal of low-temperature, safe, and effective magnetic thermotherapy. The liquid-solid phase transition material polylactic acid-glycolic acid (PLGA) approved by the FDA, is selected as raw material and superparamagnetic iron oxide nanoparticles prepared by a one-step mild reduction method are loaded to achieve magnetic resonance imaging and magnetic heating. Meanwhile, a small molecule inhibitor of heat shock protein HSP90, i. e, epigallocatechin gallate (EGCG), encapsulated in PLGA, could inhibit the body's thermal protection function and achieve the purpose of killing tumor cells at lower temperatures. In vitro results indicated that the prepared superparamagnetic iron oxide nanoparticles not only have good T-2-weighted imaging performance, but also show excellent magnetothermal transformation performance. More details, when the obtained PLGA/Fe3O4/EGCG biocomposite was controlled to heated up to 43 degrees C for 40 min under an alternating magnetic field, around 70% of tumor cell could be killed, exhibiting promising potential for low-temperature magnetothermal treatment of tumor. Such novel injectable magnetic thermal phase transition material may provide new idea and material support for the treatment of osteosarcoma.
DOI10.15541/jim20200016
WOS KeywordIRON-OXIDE NANOPARTICLES
Language中文
WOS Research AreaMaterials Science
PublisherSCIENCE PRESS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27617
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Xu, D,Zhu, YF,Zheng, YY,et al. Injectable Magnetic Liquid-solid Phase Transition Material for MR Imaging and Low-temperature Magnetocaloric Therapy of Osteosarcoma[J]. JOURNAL OF INORGANIC MATERIALS,2020(11):1277.
APA Xu, D,Zhu, YF,Zheng, YY,Luo, Y,&Chen, HR.(2020).Injectable Magnetic Liquid-solid Phase Transition Material for MR Imaging and Low-temperature Magnetocaloric Therapy of Osteosarcoma.JOURNAL OF INORGANIC MATERIALS(11),1277.
MLA Xu, D,et al."Injectable Magnetic Liquid-solid Phase Transition Material for MR Imaging and Low-temperature Magnetocaloric Therapy of Osteosarcoma".JOURNAL OF INORGANIC MATERIALS .11(2020):1277.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xu, D]'s Articles
[Zhu, YF]'s Articles
[Zheng, YY]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xu, D]'s Articles
[Zhu, YF]'s Articles
[Zheng, YY]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xu, D]'s Articles
[Zhu, YF]'s Articles
[Zheng, YY]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.