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Preparation of Mesoporous Organosilica-based Nanosystem for in vitro Synergistic Chemo- and Photothermal Therapy
Zeng, YL; Chen, JJ; Tian, ZF; Zhu, M; Zhu, YF
2020-12-20
Source PublicationJOURNAL OF INORGANIC MATERIALS
ISSN1000-324X
Issue12Pages:1365
SubtypeArticle
AbstractOrganic-inorganic hybrid mesoporous organosilica has gained more attention in biomedicine due to its high surface area, mesoporous channels, functional framework, and high drug loading capacity. In this study, disulfide-bridged hybrid mesoporous organosilica nanoparticles (MONs) as nanocarriers were employed to construct a nanosystem (ICG/DOX-MONs@DNA(20)) for delivering drugs and photothermal agents, in which DNA molecules as "switches" were modified on the surface of MONs to control drug release. The results showed that the ICG/DOX-MONs@DNA 20 nanosystem could increase the temperature to above 43 V for photothermal therapy with near-infrared (NIR) laser irradiation. On the other hand, the ICG/DOX-MONs@DNA(20) nanosystem exhibited a very slow release of DOX (12.3% in 6 h) at 37 degrees C, but a rapid release of DOX (52.4% in 6 h) occurred at 43 degrees C. Cell culture experiments indicated that the nanosystem can be internalized by HeLa cells, and exhibited an enhanced therapeutic efficacy of synergistic chemo- and photothermal therapy. Hence, the ICG/DOX-MONs@DNA(20) nanosystem might be promising for synergistic chemo- and photo-thermal tumor therapy.
DOI10.15541/jim20200091
WOS KeywordDRUG-DELIVERY ; NANOPARTICLES ; BIODEGRADABILITY ; HYPERTHERMIA
Language中文
WOS Research AreaMaterials Science
PublisherSCIENCE PRESS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27578
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Zeng, YL,Chen, JJ,Tian, ZF,et al. Preparation of Mesoporous Organosilica-based Nanosystem for in vitro Synergistic Chemo- and Photothermal Therapy[J]. JOURNAL OF INORGANIC MATERIALS,2020(12):1365.
APA Zeng, YL,Chen, JJ,Tian, ZF,Zhu, M,&Zhu, YF.(2020).Preparation of Mesoporous Organosilica-based Nanosystem for in vitro Synergistic Chemo- and Photothermal Therapy.JOURNAL OF INORGANIC MATERIALS(12),1365.
MLA Zeng, YL,et al."Preparation of Mesoporous Organosilica-based Nanosystem for in vitro Synergistic Chemo- and Photothermal Therapy".JOURNAL OF INORGANIC MATERIALS .12(2020):1365.
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