KMS Shanghai Institute of Ceramics，Chinese Academy of Sciences
| Preparation of Mesoporous Organosilica-based Nanosystem for in vitro Synergistic Chemo- and Photothermal Therapy | |
| Zeng, YL; Chen, JJ; Tian, ZF; Zhu, M; Zhu, YF | |
| 2020-12-20 | |
| Source Publication | JOURNAL OF INORGANIC MATERIALS
 |
| ISSN | 1000-324X |
| Issue | 12Pages:1365 |
| Subtype | Article |
| Abstract | Organic-inorganic hybrid mesoporous organosilica has gained more attention in biomedicine due to its high surface area, mesoporous channels, functional framework, and high drug loading capacity. In this study, disulfide-bridged hybrid mesoporous organosilica nanoparticles (MONs) as nanocarriers were employed to construct a nanosystem (ICG/DOX-MONs@DNA(20)) for delivering drugs and photothermal agents, in which DNA molecules as "switches" were modified on the surface of MONs to control drug release. The results showed that the ICG/DOX-MONs@DNA 20 nanosystem could increase the temperature to above 43 V for photothermal therapy with near-infrared (NIR) laser irradiation. On the other hand, the ICG/DOX-MONs@DNA(20) nanosystem exhibited a very slow release of DOX (12.3% in 6 h) at 37 degrees C, but a rapid release of DOX (52.4% in 6 h) occurred at 43 degrees C. Cell culture experiments indicated that the nanosystem can be internalized by HeLa cells, and exhibited an enhanced therapeutic efficacy of synergistic chemo- and photothermal therapy. Hence, the ICG/DOX-MONs@DNA(20) nanosystem might be promising for synergistic chemo- and photo-thermal tumor therapy. |
| DOI | 10.15541/jim20200091 |
| WOS Keyword | DRUG-DELIVERY ; NANOPARTICLES ; BIODEGRADABILITY ; HYPERTHERMIA |
| Language | 中文 |
| WOS Research Area | Materials Science |
| Publisher | SCIENCE PRESS |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sic.ac.cn/handle/331005/27578 |
| Collection | 中国科学院上海硅酸盐研究所 |
| Recommended Citation GB/T 7714 | Zeng, YL,Chen, JJ,Tian, ZF,et al. Preparation of Mesoporous Organosilica-based Nanosystem for in vitro Synergistic Chemo- and Photothermal Therapy[J]. JOURNAL OF INORGANIC MATERIALS,2020(12):1365. |
| APA | Zeng, YL,Chen, JJ,Tian, ZF,Zhu, M,&Zhu, YF.(2020).Preparation of Mesoporous Organosilica-based Nanosystem for in vitro Synergistic Chemo- and Photothermal Therapy.JOURNAL OF INORGANIC MATERIALS(12),1365. |
| MLA | Zeng, YL,et al."Preparation of Mesoporous Organosilica-based Nanosystem for in vitro Synergistic Chemo- and Photothermal Therapy".JOURNAL OF INORGANIC MATERIALS .12(2020):1365. |
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