SIC OpenIR
Dose-response relationships between copper and its biocompatibility/antibacterial activities
Li, Kunqiang; Xia, Chao; Qiao, Yuqin; Liu, Xuanyong
2019-09-30
Source PublicationJOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
ISSN0946-672X
Volume55Pages:127
SubtypeArticle
AbstractBackground: Copper has already been widely used in the modification of biomaterials because it possesses multifunctional biological effects like osteogenic, angiogenic and antibacterial activities. However, it is still not clear how different cell lines and bacteria will respond to different concentrations of Cu2+, which is very critical to the application of copper-doped implants. Methods: This study aimed to explore the dose-response relationships of Cu2+ and its biological effects in vitro. Rat bone marrow mesenchymal stem cell (rBMSCs), mouse osteoblastic cell line (MC3T3-E1), and human umbilical vein endothelial cells (HUVECs) were used to evaluate cellular behaviors. Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) were used to evaluate bacterial behaviors. Results: Results showed that the HUVEC5 exhibited significantly higher tolerance to copper ions than MC3T3-E1 and rBMSCs. The IC50 values of copper for HUVEC5, MC3T3-E1 and HUVEC5 were approximated to 327.9 mu M, 134.6 mu M, and 0.7 mu M, respectively. Besides, the threshold concentration of copper for effective inhibition against bacteria growth is 37 mu M. When the concentration exceeded the threshold value, antibacterial activity could increase dramatically. Conclusions: These results altogether establish a technological foundation for the application of copper-doped biomaterials in bone growth and remodeling.
KeywordCopper Antibacterial Osteogenesis Angiogenesis Dose-response relationship
DOI10.1016/j.jtemb.2019.06.015
WOS KeywordMESOPOROUS BIOACTIVE GLASS ; IN-VITRO ; ANTIBACTERIAL ACTIVITY ; SURFACE MODIFICATION ; TITANIUM SURFACE ; ANGIOGENESIS ; IMPLANTATION ; BIOCHEMISTRY ; INFECTION ; CU2+
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Endocrinology & Metabolism
PublisherELSEVIER GMBH
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27540
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Li, Kunqiang,Xia, Chao,Qiao, Yuqin,et al. Dose-response relationships between copper and its biocompatibility/antibacterial activities[J]. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY,2019,55:127.
APA Li, Kunqiang,Xia, Chao,Qiao, Yuqin,&Liu, Xuanyong.(2019).Dose-response relationships between copper and its biocompatibility/antibacterial activities.JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY,55,127.
MLA Li, Kunqiang,et al."Dose-response relationships between copper and its biocompatibility/antibacterial activities".JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY 55(2019):127.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Kunqiang]'s Articles
[Xia, Chao]'s Articles
[Qiao, Yuqin]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Kunqiang]'s Articles
[Xia, Chao]'s Articles
[Qiao, Yuqin]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Kunqiang]'s Articles
[Xia, Chao]'s Articles
[Qiao, Yuqin]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.