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Construction of Nucleus-Targeting Iridium Nanocrystals for Photonic Hyperthermia-Synergized Cancer Radiotherapy
Wang, Liying; Zhang, Tingting; Huo, Minfeng; Guo, Jia; Chen, Yu; Xu, Huixiong
2019-11-30
Source PublicationSMALL
ISSN1613-6810
Volume15Issue:47
SubtypeArticle
AbstractProminent tumor-cell nucleus targeting of radiosensitizer substantially affects the therapeutic consequence of advanced tumor radiotherapy via lethal nucleus DNA damage. Herein, ultrasmall iridium nanocrystals (Ir NCs, <5 nm) are constructed for efficient tumor-specific photonic hyperthermia-synergized radiotherapy. To endow the NCs with qualified cell nucleus-targeting performance, polyethylene glycol (PEG)-modified Ir NCs are decorated with alpha(v)beta(3) integrin-targeting cyclic arginine-glycine-aspartic (c(RGDyC)), designated as RGD, peptides and human immunodeficiency virus-1 transactivator of transcription protein(TAT), respectively, facilitating the tumor-cell-membrane (with overexpressed alpha(v)beta(3) integrin) and cell-nucleus targeting. The formulated Ir-RGD-TAT (Ir-R/T) NCs are demonstrated to accumulate inside the nucleus of tumor cells and generate effective DNA lesions upon X-ray irradiation. Further in vivo evaluations verify the satisfactory carcinoma destruction performance against 4T1 tumor xenografts. Importantly, the intriguing photonic NIR adsorption of Ir-R/T NCs has enabled the hyperthermia therapeutics accompanied with photoacoustic imaging modalities, achieving clinically promising biocompatible multifunctional radiosensitized nanoplatforms for effective tumor therapeutics.
KeywordDNA damage iridium nucleus-targeting photothermal radiotherapy
DOI10.1002/smll.201903254
WOS KeywordTOTAL MESORECTAL EXCISION ; TUMOR MICROENVIRONMENT ; RECEPTOR-BINDING ; RECTAL-CANCER ; NANOPARTICLES ; THERAPY ; DELIVERY ; GOLD ; GAMMA-H2AX ; RADIATION
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27534
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Wang, Liying,Zhang, Tingting,Huo, Minfeng,et al. Construction of Nucleus-Targeting Iridium Nanocrystals for Photonic Hyperthermia-Synergized Cancer Radiotherapy[J]. SMALL,2019,15(47).
APA Wang, Liying,Zhang, Tingting,Huo, Minfeng,Guo, Jia,Chen, Yu,&Xu, Huixiong.(2019).Construction of Nucleus-Targeting Iridium Nanocrystals for Photonic Hyperthermia-Synergized Cancer Radiotherapy.SMALL,15(47).
MLA Wang, Liying,et al."Construction of Nucleus-Targeting Iridium Nanocrystals for Photonic Hyperthermia-Synergized Cancer Radiotherapy".SMALL 15.47(2019).
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