SIC OpenIR
Negative CT Contrast Agents for the Diagnosis of Malignant Osteosarcoma
Meng, Xianfu; Zhang, Hua; Zhang, Meng; Wang, Baoming; Liu, Yanyan; Wang, Yan; Fang, Xiangming; Zhang, Jiawen; Yao, Zhenwei; Bu, Wenbo
2019-12-31
Source PublicationADVANCED SCIENCE
SubtypeArticle; Early Access
AbstractThe current positive computed tomography (CT) contrast agents (PCTCAs) including clinical iodides, present high CT density value (CT-DV). However, they are incapable for the accurate diagnosis of some diseases with high CT-DV, such as osteosarcoma. Because bones and PCTCAs around osteosarcoma generate similar X-ray attenuations. Here, an innovative strategy of negative CT contrast agents (NCTCAs) to reduce the CT-DV of osteosarcoma is proposed, contributing to accurate detection of osteosarcoma. Hollow mesoporous silica nanoparticles, loading ammonia borane molecules and further modified by polyethylene glycol, are synthesized as NCTCAs for the diagnosis of osteosarcoma. The nanocomposites can produce H-2 in situ at osteosarcoma areas by responding to the acidic microenvironment of osteosarcoma, resulting in nearly 20 times reduction of CT density in osteosarcoma. This helps form large CT density contrast between bones and osteosarcoma, and successfully achieves accurate diagnosis of osteosarcoma. Meanwhile, The NCTCAs strategy greatly expands the scope of CT application, and provides profound implications for the precise clinical diagnosis, treatment, and prognosis of diseases.
KeywordH-2 release HMSN@AB@PEG negative CT contrast agents osteosarcoma tumor acidic microenvironment
DOI10.1002/advs.201901214
WOS KeywordNERVOUS-SYSTEM LYMPHOMA ; AMMONIA-BORANE ; UP-CONVERSION ; HEART-DISEASE ; IN-VIVO ; TUMOR ; ANGIOGRAPHY ; DEHYDROGENATION ; LUMINESCENCE ; PERFORMANCE
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
PublisherWILEY
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27526
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Meng, Xianfu,Zhang, Hua,Zhang, Meng,et al. Negative CT Contrast Agents for the Diagnosis of Malignant Osteosarcoma[J]. ADVANCED SCIENCE,2019.
APA Meng, Xianfu.,Zhang, Hua.,Zhang, Meng.,Wang, Baoming.,Liu, Yanyan.,...&Bu, Wenbo.(2019).Negative CT Contrast Agents for the Diagnosis of Malignant Osteosarcoma.ADVANCED SCIENCE.
MLA Meng, Xianfu,et al."Negative CT Contrast Agents for the Diagnosis of Malignant Osteosarcoma".ADVANCED SCIENCE (2019).
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