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Manganese-Based Functional Nanoplatforms: Nanosynthetic Construction, Physiochemical Property, and Theranostic Applicability
Qian, Xiaoqin; Han, Xiaoxia; Yu, Luodan; Xu, Tianming; Chen, Yu
2019-12-31
Source PublicationADVANCED FUNCTIONAL MATERIALS
ISSN1616-301X
SubtypeReview; Early Access
AbstractTransition metal-based nanoparticles have shown their broad applications in versatile biomedical applications. Although traditional iron-based nanoparticles have been extensively explored in biomedicine, transition metal manganese (Mn)-based nanoparticulate systems have emerged as a multifunctional nanoplatform with their intrinsic physiochemical property and biological effect for satisfying the strict biomedical requirements. This comprehensive review focuses on recent progress of Mn-based functional nanoplatforms in biomedicine with the particular discussion on their elaborate construction, physiochemical property, and theranostic applicability. Several Mn-based nanosystems are discussed in detail, including solid/hollow MnOx nanoparticles, 2D MnOx nanosheets, MnOx-silica/mesoporous silica nanoparticles, MnOx-Fe3O4 nanoparticles, MnOx-Au, MnOx-fluorescent nanoparticles, Mn-based organic composite nanosystem, and some specific/unique Mn-based nanocomposites. Their versatile biomedical applications include pH/reducing-responsive T-1-weighted positive magnetic resonance imaging, controlled drug loading/delivery/release, protection of neurological disorder, photothermal hyperthermia, photodynamic therapy, chemodynamic therapy, alleviation of tumor hypoxia, immunotherapy, and some specific synergistic therapies, which are based on their disintegration behavior under the mildly acidic/reducing condition, multiple enzyme-mimicking activity, catalytic-triggering Fenton reaction, etc. The biological effects and biocompatibility of these Mn-based nanosystems are also discussed, accompanied with a discussion on challenges/critical issues and an outlook on the future developments and clinical-translation potentials of these intriguing Mn-based functional nanoplatforms.
Keywordcontrast agents magnetic resonance imaging manganese oxide manganese-based nanoparticles nanomedicine
DOI10.1002/adfm.201907066
WOS KeywordMESOPOROUS SILICA NANOPARTICLES ; GADOLINIUM OXIDE NANOPARTICLES ; MRI CONTRAST AGENTS ; PRUSSIAN BLUE NANOCUBES ; SELECTIVE DUAL FUNCTIONALIZATION ; ENHANCED PHOTODYNAMIC THERAPY ; SOLID TUMOR MICROENVIRONMENT ; TARGETED MAGNETIC-RESONANCE ; MXENES COMPOSITE NANOSHEETS ; COATED MNO NANOPARTICLES
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27495
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Qian, Xiaoqin,Han, Xiaoxia,Yu, Luodan,et al. Manganese-Based Functional Nanoplatforms: Nanosynthetic Construction, Physiochemical Property, and Theranostic Applicability[J]. ADVANCED FUNCTIONAL MATERIALS,2019.
APA Qian, Xiaoqin,Han, Xiaoxia,Yu, Luodan,Xu, Tianming,&Chen, Yu.(2019).Manganese-Based Functional Nanoplatforms: Nanosynthetic Construction, Physiochemical Property, and Theranostic Applicability.ADVANCED FUNCTIONAL MATERIALS.
MLA Qian, Xiaoqin,et al."Manganese-Based Functional Nanoplatforms: Nanosynthetic Construction, Physiochemical Property, and Theranostic Applicability".ADVANCED FUNCTIONAL MATERIALS (2019).
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