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Nanomedicine-Enabled Photonic Thermogaseous Cancer Therapy
Yin, Haohao; Guan, Xin; Lin, Han; Pu, Yinying; Fang, Yan; Yue, Wenwen; Zhou, Bangguo; Wang, Qiao; Chen, Yu; Xu, Huixiong
2019-12-31
Source PublicationADVANCED SCIENCE
SubtypeArticle; Early Access
AbstractLocal photothermal hyperthermia for tumor ablation and specific stimuliresponsive gas therapy feature the merits of remote operation, noninvasive intervention, and in situ tumor-specific activation in cancer-therapeutic biomedicine. Inspired by synergistic/sequential therapeutic modality, herein a novel therapeutic modality is reported based on the construction of two-dimensional (2D) core/shell-structured Nb2C-MSNs-SNO composite nanosheets for photonic thermogaseous therapy. A phototriggered thermogas-generating nanoreactor is designed via mesoporous silica layer coating on the surface of Nb2C MXene nanosheets, where the mesopores provide the reservoirs for NO donor (S-nitrosothiol (RSNO)), and the core of Nb2C produces heat shock upon second near-infrared biowindow (NIR-II) laser irradiation. The Nb2C-MSNs-SNO-enabled photonic thermogaseous therapy undergoes a sequential process of phototriggered heat production from the core of Nb2C and thermotriggered NO generation, together with photoacoustic-imaging (PAI) guidance and monitoring. The constructed Nb2C-MSNs-SNO nanoreactors exhibit high-NIR-induced photothermal effect, intense NIR-controlled NO release, and desirable PAI performance. Based on these unique theranostic properties of Nb2C-MSNs-SNO nanocomposites, sequential photonic thermogaseous therapy with limited systematic toxicity on efficiently suppressing tumor growth is achieved by PAI-guided NIR-controlled NO release as well as heat generation. Such a thermogaseous approach representes a stimuli-selective strategy for synergistic/sequential cancer treatment.
KeywordMXene nitric oxide photonic nanomedicine sequential activation thermogaseous therapy
DOI10.1002/advs.201901954
WOS KeywordNITRIC-OXIDE DONORS ; PHOTODYNAMIC THERAPY ; CHECKPOINT BLOCKADE ; TUMOR ; COMBINATION ; RELEASE ; GENERATION ; NANOSHEETS ; PLATFORM ; MXENES
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
PublisherWILEY
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27481
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Yin, Haohao,Guan, Xin,Lin, Han,et al. Nanomedicine-Enabled Photonic Thermogaseous Cancer Therapy[J]. ADVANCED SCIENCE,2019.
APA Yin, Haohao.,Guan, Xin.,Lin, Han.,Pu, Yinying.,Fang, Yan.,...&Xu, Huixiong.(2019).Nanomedicine-Enabled Photonic Thermogaseous Cancer Therapy.ADVANCED SCIENCE.
MLA Yin, Haohao,et al."Nanomedicine-Enabled Photonic Thermogaseous Cancer Therapy".ADVANCED SCIENCE (2019).
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