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2D MXene-Integrated 3D-Printing Scaffolds for Augmented Osteosarcoma Phototherapy and Accelerated Tissue Reconstruction
Pan, Shanshan; Yin, Junhui; Yu, Luodan; Zhang, Changqing; Zhu, Yufang; Gao, Youshui; Chen, Yu
2019-12-31
Source PublicationADVANCED SCIENCE
SubtypeArticle; Early Access
AbstractThe residual of malignant tumor cells and lack of bone-tissue integration are the two critical concerns of bone-tumor recurrence and surgical failure. In this work, the rational integration of 2D Ti3C2 MXene is reported with 3D-printing bioactive glass (BG) scaffolds for achieving concurrent bone-tumor killing by photonic hyperthermia and bone-tissue regeneration by bioactive scaffolds. The designed composite scaffolds take the unique feature of high photothermal conversion of integrated 2D Ti3C2 MXene for inducing bone-tumor ablation by near infrared-triggered photothermal hyperthermia, which has achieved the complete tumor eradication on in vivo bone-tumor xenografts. Importantly, the rational integration of 2D Ti3C2 MXene is demonstrated to efficiently accelerate the in vivo growth of newborn bone tissue of the composite BG scaffolds. The dual functionality of bone-tumor killing and bone-tissue regeneration makes these Ti3C2 MXene-integrated composite scaffolds highly promising for the treatment of bone tumors, which also substantially broadens the biomedical applications of 2D MXenes in tissue engineering, especially on the treatment of bone tumors.
Keywordbone tumors MXenes photothermal therapy scaffolds tissue engineering
DOI10.1002/advs.201901511
WOS KeywordTUMOR-THERAPY ; ANIMAL-MODELS ; STEM-CELLS ; BONE ; NANOSHEETS ; TITANIUM ; NIOBIUM ; MOUSE ; DIFFERENTIATION ; NANOCRYSTALS
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
PublisherWILEY
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27480
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Pan, Shanshan,Yin, Junhui,Yu, Luodan,et al. 2D MXene-Integrated 3D-Printing Scaffolds for Augmented Osteosarcoma Phototherapy and Accelerated Tissue Reconstruction[J]. ADVANCED SCIENCE,2019.
APA Pan, Shanshan.,Yin, Junhui.,Yu, Luodan.,Zhang, Changqing.,Zhu, Yufang.,...&Chen, Yu.(2019).2D MXene-Integrated 3D-Printing Scaffolds for Augmented Osteosarcoma Phototherapy and Accelerated Tissue Reconstruction.ADVANCED SCIENCE.
MLA Pan, Shanshan,et al."2D MXene-Integrated 3D-Printing Scaffolds for Augmented Osteosarcoma Phototherapy and Accelerated Tissue Reconstruction".ADVANCED SCIENCE (2019).
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