SIC OpenIR
Bioinspired multifunctional biomaterials with hierarchical microstructure for wound dressing
Xue, Jianmin; Wang, Xiaocheng; Wang, Endian; Li, Tian; Chang, Jiang; Wu, Chengtie
2019-12-30
Source PublicationACTA BIOMATERIALIA
ISSN1742-7061
Volume100Pages:270
SubtypeArticle
AbstractDeveloping multifunctional wound dressing with desired mechanical strength is of great significance for the treatment of different types of skin wounds. Inspired by the close relationship between strength and hierarchical structure of nacre, hierarchical and porous graphene oxide-chitosan-calcium silicate (GO-CTS-CS) film biomaterials are fabricated by a combination of vacuum filtration-assisted assembly and freeze-drying methods. The bioinspired hierarchical materials emulate an orderly porous lamellar micron-scale structure and the "brick-and-mortar"-layered nanostructure. The hierarchical microstructure endows the GO-CTS-CS biomaterials with good tensile strength, compatible breathability, and water absorption. Furthermore, the hierarchical GO-CTS-CS biomaterials exhibit ideal photothermal performance, leading to significant photothermal antibacterial and antitumor efficacy. Further, the hierarchical GO-CTS-CS biomaterials show stimulatory effect on in vivo chronic wound healing. Therefore, such a high performance and multifunctional biomaterial is believed to offer a promising alternative to traditional wound dressing in future. Statement of Significance Although it is an effective strategy to prepare high-performance materials by mimicking the hierarchical microstructure of nacre, the preparation of nacre-inspired materials in tissue engineering fields still needs to be investigated. In this work, we prepared a nacre-inspired multifunctional graphene oxide-chitosancalcium silicate (GO-CTS-CS) biomaterial with a hierarchical microstructure. The hierarchical microstructure endows the biomaterials with desired properties of strength, breathability, and water absorption. Further, the hierarchical GO-CTS-CS biomaterial showed good photothermal antibacterial/antitumor and wound healing effects. This work may provide an approach to combine the preparation of multifunctional biomaterials with bioinspired engineering by constructing a hierarchical microstructure, indicating that the assembling hierarchical microstructure in biomaterials is of great importance for tissue engineering and regenerative medicine. (C) 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
KeywordHierarchical structure Bioinspired materials Multifunctional materials Photothermal antibacterial and antitumor Wound healing
DOI10.1016/j.actbio.2019.10.012
WOS KeywordPHOTODYNAMIC THERAPY ; COMPOSITE FILM ; DRUG-DELIVERY ; TUMOR-THERAPY ; CHITOSAN ; NANOCOMPOSITES ; HYDROGELS ; NACRE ; ION ; PROPERTY
Language英语
WOS Research AreaEngineering ; Materials Science
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27460
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Xue, Jianmin,Wang, Xiaocheng,Wang, Endian,et al. Bioinspired multifunctional biomaterials with hierarchical microstructure for wound dressing[J]. ACTA BIOMATERIALIA,2019,100:270.
APA Xue, Jianmin,Wang, Xiaocheng,Wang, Endian,Li, Tian,Chang, Jiang,&Wu, Chengtie.(2019).Bioinspired multifunctional biomaterials with hierarchical microstructure for wound dressing.ACTA BIOMATERIALIA,100,270.
MLA Xue, Jianmin,et al."Bioinspired multifunctional biomaterials with hierarchical microstructure for wound dressing".ACTA BIOMATERIALIA 100(2019):270.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xue, Jianmin]'s Articles
[Wang, Xiaocheng]'s Articles
[Wang, Endian]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xue, Jianmin]'s Articles
[Wang, Xiaocheng]'s Articles
[Wang, Endian]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xue, Jianmin]'s Articles
[Wang, Xiaocheng]'s Articles
[Wang, Endian]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.