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Three-Dimensional-Printed Bioceramic Scaffolds with Osteogenic Activity for Simultaneous Photo/Magnetothermal Therapy of Bone Tumors
Zhuang, Hui; Lin, Rongcai; Liu, Yaqin; Zhang, Meng; Zhai, Dong; Huan, Zhiguang; Wu, Chengtie
2019-12-30
Source PublicationACS BIOMATERIALS SCIENCE & ENGINEERING
ISSN2373-9878
Volume5Issue:12Pages:6725
SubtypeArticle
AbstractFor the postoperative treatment of bone cancer, biomaterials should possess an antitumor effect and simultaneous repair ability of bone defects. Compared with single photothermal treatment or magnetothermal treatment, photo/magnetothermal joint treatment represents a more high-efficient strategy to kill tumor cells. In this work, a 3D-printed bioceramic scaffold with a photo/magnetothermal effect was successfully designed and fabricated, which exhibited the function of killing tumor cells and excellent osteogenic bioactivity, via incorporating an Fe element into akermanite (AKT) bioceramics. After doping with ferric elements, the AKT scaffolds possessed significantly enhanced compressive strength and desirable ferromagnetic property. The ferric elements endowed the AKT scaffolds with excellent photo/magnetothermal effects, and hence the scaffolds could efficiently kill tumor cells in vitro under mild laser power density and magnetic field. In addition, the Fe-doped AKT bioceramic scaffolds significantly promoted cell proliferation and osteogenic differentiation of rabbit bone mesenchymal stem cells as compared with the original AKT scaffolds without Fe elements. The results suggest that Fe-doped bioceramic scaffolds with both photo/magnetothermal effect and in vitro osteogenic bioactivity could be a promising biomaterial for the synergistic therapy of bone cancers.
Keywordakermanite scaffolds photo/magnetothermal treatment tumor therapy osteogenic bioactivity
DOI10.1021/acsbiomaterials.9b01095
WOS KeywordIN-VITRO ; PHOTOTHERMAL THERAPY ; IONIC PRODUCTS ; HYPERTHERMIA ; HYDROXYAPATITE ; NANOPARTICLES ; NANOSTRUCTURES ; PROLIFERATION ; BIOMATERIALS ; DISSOLUTION
Language英语
WOS Research AreaMaterials Science
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27459
Collection中国科学院上海硅酸盐研究所
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GB/T 7714
Zhuang, Hui,Lin, Rongcai,Liu, Yaqin,et al. Three-Dimensional-Printed Bioceramic Scaffolds with Osteogenic Activity for Simultaneous Photo/Magnetothermal Therapy of Bone Tumors[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2019,5(12):6725.
APA Zhuang, Hui.,Lin, Rongcai.,Liu, Yaqin.,Zhang, Meng.,Zhai, Dong.,...&Wu, Chengtie.(2019).Three-Dimensional-Printed Bioceramic Scaffolds with Osteogenic Activity for Simultaneous Photo/Magnetothermal Therapy of Bone Tumors.ACS BIOMATERIALS SCIENCE & ENGINEERING,5(12),6725.
MLA Zhuang, Hui,et al."Three-Dimensional-Printed Bioceramic Scaffolds with Osteogenic Activity for Simultaneous Photo/Magnetothermal Therapy of Bone Tumors".ACS BIOMATERIALS SCIENCE & ENGINEERING 5.12(2019):6725.
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