KMS Shanghai Institute of Ceramics，Chinese Academy of Sciences
| Regulating the Behavior of Human Gingival Fibroblasts by sp(2) Domains in Reduced Graphene Oxide | |
| Wang, Lanyu; Qiu, Jiajun; Guo, Jingshu; Wang, Donghui; Qian, Shi; Cao, Huiliang; Liu, Xuanyong | |
| 2019-12-30 | |
| Source Publication | ACS BIOMATERIALS SCIENCE & ENGINEERING
 |
| ISSN | 2373-9878 |
| Volume | 5Issue:12Pages:6414 |
| Subtype | Article |
| Abstract | Long-term function of dental implants relies on not only stable osseointegration but also strong soft tissue-sealing ability. Ideal soft tissue sealing around implants is an effective protective barrier between the external environment and alveolar bone, preventing the invasion of bacteria that is considered as a vital trigger of irreversible marginal bone loss. Carbon-based materials have been reported to be beneficial to soft tissue sealing, which can be regulated through the hybridization type of carbon atoms (sp(2) or sp(3)), but its internal mechanism is still not clear. In this work, graphene oxide with both sp(2) - and sp(3)-hybridized carbons was electrophoretic deposited on titanium and reduced to regulate the hybridization type of carbon atoms to investigate its effect and possible mechanism on human gingival fibroblasts (HGFs). X- ray photoelectron spectroscopy and Raman mapping test show the increase of sp(2) domain content and the decrease of their size after reduction. Through computer simulation, the possible mechanism of the decrease of sp(2) domain size was proposed. In vitro studies disclose that the HGFs exhibit higher proliferation rate, better adhesion, and migration ability with the increase of sp(2) domains and the decrease of their sizes. It may be due to the amount and size of sp(2) domains that synergistically regulate the amount and properties of adsorbed proteins, thereby influencing the cellular behaviors of HGFs. Our results may offer a different perspective on material designing and academic research to enhance the soft tissue integration of implants. |
| Keyword | human gingival fibroblasts soft tissue sealing reduced graphene oxide sp(2) domains |
| DOI | 10.1021/acsbiomaterials.9b00497 |
| WOS Keyword | CARBON NANOTUBES ; IN-VITRO ; AQUEOUS DISPERSIONS ; GRAPHITE OXIDE ; TITANIUM ; REDUCTION ; NANOSHEETS ; MECHANISM ; SURFACE ; FILMS |
| Language | 英语 |
| WOS Research Area | Materials Science |
| Publisher | AMER CHEMICAL SOC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sic.ac.cn/handle/331005/27458 |
| Collection | 中国科学院上海硅酸盐研究所 |
| Recommended Citation GB/T 7714 | Wang, Lanyu,Qiu, Jiajun,Guo, Jingshu,et al. Regulating the Behavior of Human Gingival Fibroblasts by sp(2) Domains in Reduced Graphene Oxide[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2019,5(12):6414. |
| APA | Wang, Lanyu.,Qiu, Jiajun.,Guo, Jingshu.,Wang, Donghui.,Qian, Shi.,...&Liu, Xuanyong.(2019).Regulating the Behavior of Human Gingival Fibroblasts by sp(2) Domains in Reduced Graphene Oxide.ACS BIOMATERIALS SCIENCE & ENGINEERING,5(12),6414. |
| MLA | Wang, Lanyu,et al."Regulating the Behavior of Human Gingival Fibroblasts by sp(2) Domains in Reduced Graphene Oxide".ACS BIOMATERIALS SCIENCE & ENGINEERING 5.12(2019):6414. |
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