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Regulating the Behavior of Human Gingival Fibroblasts by sp(2) Domains in Reduced Graphene Oxide
Wang, Lanyu; Qiu, Jiajun; Guo, Jingshu; Wang, Donghui; Qian, Shi; Cao, Huiliang; Liu, Xuanyong
2019-12-30
Source PublicationACS BIOMATERIALS SCIENCE & ENGINEERING
ISSN2373-9878
Volume5Issue:12Pages:6414
SubtypeArticle
AbstractLong-term function of dental implants relies on not only stable osseointegration but also strong soft tissue-sealing ability. Ideal soft tissue sealing around implants is an effective protective barrier between the external environment and alveolar bone, preventing the invasion of bacteria that is considered as a vital trigger of irreversible marginal bone loss. Carbon-based materials have been reported to be beneficial to soft tissue sealing, which can be regulated through the hybridization type of carbon atoms (sp(2) or sp(3)), but its internal mechanism is still not clear. In this work, graphene oxide with both sp(2) - and sp(3)-hybridized carbons was electrophoretic deposited on titanium and reduced to regulate the hybridization type of carbon atoms to investigate its effect and possible mechanism on human gingival fibroblasts (HGFs). X- ray photoelectron spectroscopy and Raman mapping test show the increase of sp(2) domain content and the decrease of their size after reduction. Through computer simulation, the possible mechanism of the decrease of sp(2) domain size was proposed. In vitro studies disclose that the HGFs exhibit higher proliferation rate, better adhesion, and migration ability with the increase of sp(2) domains and the decrease of their sizes. It may be due to the amount and size of sp(2) domains that synergistically regulate the amount and properties of adsorbed proteins, thereby influencing the cellular behaviors of HGFs. Our results may offer a different perspective on material designing and academic research to enhance the soft tissue integration of implants.
Keywordhuman gingival fibroblasts soft tissue sealing reduced graphene oxide sp(2) domains
DOI10.1021/acsbiomaterials.9b00497
WOS KeywordCARBON NANOTUBES ; IN-VITRO ; AQUEOUS DISPERSIONS ; GRAPHITE OXIDE ; TITANIUM ; REDUCTION ; NANOSHEETS ; MECHANISM ; SURFACE ; FILMS
Language英语
WOS Research AreaMaterials Science
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27458
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Wang, Lanyu,Qiu, Jiajun,Guo, Jingshu,et al. Regulating the Behavior of Human Gingival Fibroblasts by sp(2) Domains in Reduced Graphene Oxide[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2019,5(12):6414.
APA Wang, Lanyu.,Qiu, Jiajun.,Guo, Jingshu.,Wang, Donghui.,Qian, Shi.,...&Liu, Xuanyong.(2019).Regulating the Behavior of Human Gingival Fibroblasts by sp(2) Domains in Reduced Graphene Oxide.ACS BIOMATERIALS SCIENCE & ENGINEERING,5(12),6414.
MLA Wang, Lanyu,et al."Regulating the Behavior of Human Gingival Fibroblasts by sp(2) Domains in Reduced Graphene Oxide".ACS BIOMATERIALS SCIENCE & ENGINEERING 5.12(2019):6414.
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