Biodegradable Nanoprodrugs: "Delivering" ROS to Cancer Cells for Molecular Dynamic Therapy

doi:10.1002/adma.201904011

SIC OpenIR

	Biodegradable Nanoprodrugs: "Delivering" ROS to Cancer Cells for Molecular Dynamic Therapy
	Tang, Zhong-min; Liu, Yan-yan; Ni, Da-long; Zhou, Jia-jia; Zhang, Meng; Zhao, Pei-ran; Lv, Bin; Wang, Han; Jin, Da-yong; Bu, Wen-bo
	2019-12-31
Source Publication	ADVANCED MATERIALS
ISSN	0935-9648
Subtype	Article; Early Access
Abstract	Biodegradable nanoprodrugs, inheriting the antitumor effects of chemotherapy drugs and overcoming the inevitable drawback of side effects on normal tissues, hold promise as next-generation cancer therapy candidates. Biodegradable nanoprodrugs of transferrin-modified MgO2 nanosheets are developed to selectively deliver reactive oxygen species to cancer cells for molecular dynamic therapy strategy. The nanosheets favor the acidic and low catalase activity tumor microenvironment to react with proton and release nontoxic Mg2+. This reaction simultaneously produces abundant H2O2 to induce cell death and damage the structure of transferrin to release Fe3+, which will react with H2O2 to produce highly toxic center dot OH to kill tumor cells.
Keyword	biodegradable nanoprodrugs MgO2 nanosheets molecular dynamic therapy tumor microenvironment
DOI	10.1002/adma.201904011
WOS Keyword	REACTIVE OXYGEN ; HYDROGEN-PEROXIDE ; GROWTH ; TRANSDUCTION ; MAGNESIUM
Language	英语
WOS Research Area	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
Publisher	WILEY-V C H VERLAG GMBH
Citation statistics
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/27455
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Tang, Zhong-min,Liu, Yan-yan,Ni, Da-long,et al. Biodegradable Nanoprodrugs: "Delivering" ROS to Cancer Cells for Molecular Dynamic Therapy[J]. ADVANCED MATERIALS,2019.
APA	Tang, Zhong-min.,Liu, Yan-yan.,Ni, Da-long.,Zhou, Jia-jia.,Zhang, Meng.,...&Bu, Wen-bo.(2019).Biodegradable Nanoprodrugs: "Delivering" ROS to Cancer Cells for Molecular Dynamic Therapy.ADVANCED MATERIALS.
MLA	Tang, Zhong-min,et al."Biodegradable Nanoprodrugs: "Delivering" ROS to Cancer Cells for Molecular Dynamic Therapy".ADVANCED MATERIALS (2019).

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