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Photosynthetic Tumor Oxygenation by Photosensitizer-Containing Cyanobacteria for Enhanced Photodynamic Therapy
Huo, Minfeng; Wang, Liying; Zhang, Linlin; Wei, Chenyang; Chen, Yu; Shi, Jianlin
2019-12-31
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
SubtypeArticle; Early Access
AbstractSustained tumor oxygenation is of critical importance during type-II photodynamic therapy (PDT), which depends on the intratumoral oxygen level for the generation of reactive oxygen species. Herein, the modification of photosynthetic cyanobacteria with the photosensitizer chlorin e6 (ce6) to form ce6-integrated photosensitive cells, termed ceCyan, is reported. Upon 660 nm laser irradiation, sustained photosynthetic O-2 evolution by the cyanobacteria and the immediate generation of reactive singlet oxygen species (O-1(2)) by the integrated photosensitizer could be almost simultaneously achieved for tumor therapy using type-II PDT both in vitro and in vivo. This work contributes a conceptual while practical paradigm for biocompatible and effective PDT using hybrid microorganisms, displaying a bright future in clinical PDT by microbiotic nanomedicine.
Keywordcyanobacteria oxygenation photodynamic therapy photosensitizers photosynthesis
DOI10.1002/anie.201912824
WOS KeywordBACTERIA ; NANOPARTICLES ; CANCER
Language英语
WOS Research AreaChemistry
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27452
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Huo, Minfeng,Wang, Liying,Zhang, Linlin,et al. Photosynthetic Tumor Oxygenation by Photosensitizer-Containing Cyanobacteria for Enhanced Photodynamic Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019.
APA Huo, Minfeng,Wang, Liying,Zhang, Linlin,Wei, Chenyang,Chen, Yu,&Shi, Jianlin.(2019).Photosynthetic Tumor Oxygenation by Photosensitizer-Containing Cyanobacteria for Enhanced Photodynamic Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.
MLA Huo, Minfeng,et al."Photosynthetic Tumor Oxygenation by Photosensitizer-Containing Cyanobacteria for Enhanced Photodynamic Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019).
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