SIC OpenIR
An Adaptable Nanoplatform for Integrating Anatomic and Functional Magnetic Resonance Imaging under a 3.0 T Magnetic Field
Shen, Aijun; Meng, Xianfu; Gao, Xiaolong; Xu, Xiaowen; Shoo, Chulun; Tang, Zhongmin; Liu, Yanyan; Bu, Wenbo; Wang, Peijun
2019
Source PublicationADVANCED FUNCTIONAL MATERIALS
ISSN1616-301X
Volume29Issue:2
SubtypeArticle
AbstractIt is well known that acidic tumor microenvironment (TME) is very important for tumor' growth, metastasis, and drug resistance. In addition, accurate diagnosis of the solid tumors' acidic microenviroment based on the precise location of their site is especially essential for the further treatment and prognostic evaluation of cancer. Although magnetic resonance imaging (MRI) is widely used for clinical cancer diagnosis, there are still enormous challenges left for developing MRI agents which integrate anatomic imaging for tumor site location with functional imaging for pH evaluation, especially for medium or high magnetic field machines. Herein, an innovative strategy is proposed to incorporate anatomic imaging (T-1-weighted imaging, T1WI) with functional imaging (susceptibility weighted imaging, SWI) using one 3.0 T MRI scanner on an adaptable nanoplatform namely, NaGdF4@polydopamine@polyethylene glycol (PEG), which can self-aggregate under the specific low pH in TME to realize regulatory susceptibility. Moreover, the nanoplatform performs well in tumor accurately location as well as pH sensitively perception. Most importantly, the strategy not only fuses two MRI models on one nanoplatform using one 3.0 T machine to extend the application range but also provides a new insight for the design of other novel imaging agents.
Keywordacidic tumor microenvironment NaGdF4@PDA@PEG nanoprobes self-aggregates SWI T1WI
DOI10.1002/adfm.201803832
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27430
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Shen, Aijun,Meng, Xianfu,Gao, Xiaolong,et al. An Adaptable Nanoplatform for Integrating Anatomic and Functional Magnetic Resonance Imaging under a 3.0 T Magnetic Field[J]. ADVANCED FUNCTIONAL MATERIALS,2019,29(2).
APA Shen, Aijun.,Meng, Xianfu.,Gao, Xiaolong.,Xu, Xiaowen.,Shoo, Chulun.,...&Wang, Peijun.(2019).An Adaptable Nanoplatform for Integrating Anatomic and Functional Magnetic Resonance Imaging under a 3.0 T Magnetic Field.ADVANCED FUNCTIONAL MATERIALS,29(2).
MLA Shen, Aijun,et al."An Adaptable Nanoplatform for Integrating Anatomic and Functional Magnetic Resonance Imaging under a 3.0 T Magnetic Field".ADVANCED FUNCTIONAL MATERIALS 29.2(2019).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Shen, Aijun]'s Articles
[Meng, Xianfu]'s Articles
[Gao, Xiaolong]'s Articles
Baidu academic
Similar articles in Baidu academic
[Shen, Aijun]'s Articles
[Meng, Xianfu]'s Articles
[Gao, Xiaolong]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Shen, Aijun]'s Articles
[Meng, Xianfu]'s Articles
[Gao, Xiaolong]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.