Inlaying Radiosensitizer onto the Polypeptide Shell of Drug-Loaded Ferritin for Imaging and Combinational Chemo-Radiotherapy

doi:10.7150/thno.33472

SIC OpenIR

	Inlaying Radiosensitizer onto the Polypeptide Shell of Drug-Loaded Ferritin for Imaging and Combinational Chemo-Radiotherapy
	Zhang, Qiuhong; Chen, Jingwen; Shen, Jie; Chen, Shixiong; Liang, Kaicheng; Wang, Han; Chen, Hangrong
	2019
Source Publication	THERANOSTICS
ISSN	1838-7640
Volume	9 Issue:10 Pages:2779
Subtype	Article
Abstract	Rationale: Ferritin with unique hollow cavity is an emerging protein-based nanoplatform for anticancer-drug delivery, but the in vivo chemotherapeutic effectiveness is still unsatisfactory with such a monotherapy modality, which is urgently in need of improvement. Methods: Here a novel ferritin nanotheranostic with anticancer-drug doxorubicin encapsulated into its hollow interior and nanoradiosensitizer bismuth sulfide nanocrystals inlayed onto its polypeptide shell was synthesized for combinational therapeutic benefits. The formation mechanism of bismuth sulfide nanocrystals based on ferritin has been analyzed. The in vitro and in vivo treatment effects were carried out on HeLa cancer cells and tumor-bearing mice, respectively. The biocompatibility and excretion of the ferritin nanotheranostic have also been evaluated to guarantee their biosafety. Results: The polypeptide shell of ferritin provides nucleation sites for the bismuth sulfide nanocrystals through coordination interaction, and simultaneously inhibits the further growth of bismuth sulfide nanocrystals, rendering the bismuth sulfide nanocrystals like rivets inlaying onto the polypeptide firmly, which can not only strengthen the architectural stability of ferritin to prevent drug burst leakage during systemic circulation, but also act as excellent computed tomography contrast agents and nanoradiosensitizers for in vivo imaging-guided cancer combinational treatments. Conclusions: The design concept of inlaying bismuth sulfide nanocrystals onto the polypeptide shell of doxorubicin-encapsulated ferritin significantly inhibits the tumor growth and simultaneously further broadens the application of ferritin in nanomedicine.
Keyword	ferritin radiotherapy chemotherapy polypeptide subunit bismuth sulfide
DOI	10.7150/thno.33472
Language	英语
WOS Research Area	Research & Experimental Medicine
Publisher	IVYSPRING INT PUBL
Citation statistics	Cited Times:7[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/27415
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Zhang, Qiuhong,Chen, Jingwen,Shen, Jie,et al. Inlaying Radiosensitizer onto the Polypeptide Shell of Drug-Loaded Ferritin for Imaging and Combinational Chemo-Radiotherapy[J]. THERANOSTICS,2019,9(10):2779.
APA	Zhang, Qiuhong.,Chen, Jingwen.,Shen, Jie.,Chen, Shixiong.,Liang, Kaicheng.,...&Chen, Hangrong.(2019).Inlaying Radiosensitizer onto the Polypeptide Shell of Drug-Loaded Ferritin for Imaging and Combinational Chemo-Radiotherapy.THERANOSTICS,9(10),2779.
MLA	Zhang, Qiuhong,et al."Inlaying Radiosensitizer onto the Polypeptide Shell of Drug-Loaded Ferritin for Imaging and Combinational Chemo-Radiotherapy".THERANOSTICS 9.10(2019):2779.

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