SIC OpenIR
Copper-incorporated bioactive glass-ceramics inducing anti-inflammatory phenotype and regeneration of cartilage/bone interface
Lin, Rongcai; Deng, Cuijun; Li, Xuxiang; Liu, Yaqin; Zhang, Meng; Qin, Chen; Yao, Qingqiang; Wang, Liming; Wu, Chengtie
2019
Source PublicationTHERANOSTICS
ISSN1838-7640
Volume9Issue:21Pages:6300
SubtypeArticle
AbstractOsteoarthritis not only results in cartilage lesion, but also is accompanied with subchondral bone damage caused by the inflammatory response. It is of great significance to treat osteoarthritis by regulating the immune response. As copper (Cu) plays an essential role in immune response and anti-arthritis, a copper-incorporated bioactive glass-ceramics (Cu-BGC) may achieve the aim of healing cartilage lesion and reducing inflammatory response caused by osteoarthritis. We hypothesized that the Cu2+ released from Cu-BGC scaffolds may satisfy the requirements of cartilage regeneration and anti-arthritis. Methods: 3D-printing method was employed to prepare Cu-BGC scaffolds. The stimulating effect on the chondrocytes and macrophages cultured with Cu-BGC extracts was investigated. Furthermore, the in vivo regenerative effect of Cu-BGC scaffolds on osteochondral defects was studied. Results: The incorporation of Cu2+ into BGC considerably promoted the proliferation and maturation of chondrocytes, and induced macrophages shifting to anti-inflammatory phenotype. Histological analysis demonstrated that the Cu-BGC scaffolds meaningfully improved the regeneration of cartilage and elevated the recovery of the osteochondral interface as compared with the CTR and BGC groups. The potential mechanism is related to Cu2+ ions triggering the immune response of cartilage via activating HIF signaling pathway and inhibiting the inflammatory response in osteochondral tissue. Conclusion: These results demonstrated that Cu-BGC scaffolds significantly facilitated the regeneration of cartilage and osteochondral interface, as well as inhibited inflammatory response, which may prevent the development of osteoarthritis associated with osteochondral defects.
Keywordcopper bioactive glass ceramics osteoarthritis cartilage regeneration immunomodulation
DOI10.7150/thno.36120
Language英语
WOS Research AreaResearch & Experimental Medicine
PublisherIVYSPRING INT PUBL
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27412
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Lin, Rongcai,Deng, Cuijun,Li, Xuxiang,et al. Copper-incorporated bioactive glass-ceramics inducing anti-inflammatory phenotype and regeneration of cartilage/bone interface[J]. THERANOSTICS,2019,9(21):6300.
APA Lin, Rongcai.,Deng, Cuijun.,Li, Xuxiang.,Liu, Yaqin.,Zhang, Meng.,...&Wu, Chengtie.(2019).Copper-incorporated bioactive glass-ceramics inducing anti-inflammatory phenotype and regeneration of cartilage/bone interface.THERANOSTICS,9(21),6300.
MLA Lin, Rongcai,et al."Copper-incorporated bioactive glass-ceramics inducing anti-inflammatory phenotype and regeneration of cartilage/bone interface".THERANOSTICS 9.21(2019):6300.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Lin, Rongcai]'s Articles
[Deng, Cuijun]'s Articles
[Li, Xuxiang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Lin, Rongcai]'s Articles
[Deng, Cuijun]'s Articles
[Li, Xuxiang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Lin, Rongcai]'s Articles
[Deng, Cuijun]'s Articles
[Li, Xuxiang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.