Ion Therapy: A Novel Strategy for Acute Myocardial Infarction

doi:10.1002/advs.201801260

SIC OpenIR

	Ion Therapy: A Novel Strategy for Acute Myocardial Infarction
	Yi, Min; Li, Hekai; Wong, Xiaoya; Yan, Jianyun; Gao, Long; He, Yinyan; Zhong, Xinglong; Cai, Yanbin; Feng, Weijing; Wen, Zhanpeng; Wu, Chengtie; Ou, Caiwen; Chang, Jiang; Chen, Minsheng
	2019-01-09
Source Publication	ADVANCED SCIENCE
ISSN	2198-3844
Volume	6 Issue:1
Subtype	Article
Abstract	Although numerous therapies are widely applied clinically and stem cells and/or biomaterial based in situ implantations have achieved some effects, few of these have observed robust myocardial regeneration. The beneficial effects on cardiac function and structure are largely acting through paracrine signaling, which preserve the border-zone around the infarction, reduce apoptosis, blunt adverse remodeling, and promote angiogenesis. Ionic extracts from biomaterials have been proven to stimulate paracrine effects and promote cell-cell communications. Here, the paracrine stimulatory function of bioactive ions derived from biomaterials is integrated into the clinical concept of administration and proposed "ion therapy" as a novel strategy for myocardial infarction. In vitro, silicon- enriched ion extracts significantly increase cardiomyocyte viability and promote cell-cell communications, thus stimulating vascular formation via a paracrine effect under glucose/oxygen deprived conditions. In vivo, by intravenous injection, the bioactive silicon ions act as "diplomats" and promote crosstalk in myocardial cells, stimulate angiogenesis, and improve cardiac function post-myocardial infarction.
Keyword	acute myocardial infarction bioactive ions therapy
DOI	10.1002/advs.201801260
Language	英语
WOS Research Area	Chemistry ; Science & Technology - Other Topics ; Materials Science
Publisher	WILEY
Citation statistics	Cited Times:6[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/27404
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Yi, Min,Li, Hekai,Wong, Xiaoya,et al. Ion Therapy: A Novel Strategy for Acute Myocardial Infarction[J]. ADVANCED SCIENCE,2019,6(1).
APA	Yi, Min.,Li, Hekai.,Wong, Xiaoya.,Yan, Jianyun.,Gao, Long.,...&Chen, Minsheng.(2019).Ion Therapy: A Novel Strategy for Acute Myocardial Infarction.ADVANCED SCIENCE,6(1).
MLA	Yi, Min,et al."Ion Therapy: A Novel Strategy for Acute Myocardial Infarction".ADVANCED SCIENCE 6.1(2019).

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