SIC OpenIR
Upconversion-based photodynamic cancer therapy
Liu, Yanyan; Meng, Xianfu; Bu, Wenbo
2019-01-15
Source PublicationCOORDINATION CHEMISTRY REVIEWS
ISSN0010-8545
Volume379Pages:82
SubtypeReview
AbstractPhotodynamic therapy (PDT) has become widely accepted and utilized for tumor therapy. Considering the natural shortcomings (e.g., lack of an ideal photosensitizer and limited light penetration depth), lanthanide doped upconversion nanoparticles (Ln-doped UCNP), which can be excited with near-infrared light (NIR) for UV/visible/NIR upconversion luminescence (UCL) emissions, show great potential for augmenting biological treatment with PDT for solid tumors and for visual bioimaging of disease lesions. This review summarizes the basic concepts and important influence factors on PDT, the optimized construction of UCNP-based photosensitizer (UCNP-PS) systems, and some representative examples of UCNP-based PDT (UCPDT) applications in combination with other traditional therapy methods, such as chemotherapy, radiotherapy, photothermal therapy (PIT) and gene therapy. This review will provide guidance for the design and fabrication of future new UCNP-based nanocomposites for synergistic UC-PDT therapy. (C) 2017 Elsevier B.V. All rights reserved.
KeywordPhotodynamic therapy Upconversion nanoparticles Photosensitizers UCNP-based PDT Synergistic therapy
DOI10.1016/j.ccr.2017.09.006
Language英语
WOS Research AreaChemistry
PublisherELSEVIER SCIENCE SA
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27396
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Liu, Yanyan,Meng, Xianfu,Bu, Wenbo. Upconversion-based photodynamic cancer therapy[J]. COORDINATION CHEMISTRY REVIEWS,2019,379:82.
APA Liu, Yanyan,Meng, Xianfu,&Bu, Wenbo.(2019).Upconversion-based photodynamic cancer therapy.COORDINATION CHEMISTRY REVIEWS,379,82.
MLA Liu, Yanyan,et al."Upconversion-based photodynamic cancer therapy".COORDINATION CHEMISTRY REVIEWS 379(2019):82.
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