Upconversion-based photodynamic cancer therapy

doi:10.1016/j.ccr.2017.09.006

SIC OpenIR

	Upconversion-based photodynamic cancer therapy
	Liu, Yanyan; Meng, Xianfu; Bu, Wenbo
	2019-01-15
Source Publication	COORDINATION CHEMISTRY REVIEWS
ISSN	0010-8545
Volume	379 Pages:82
Subtype	Review
Abstract	Photodynamic therapy (PDT) has become widely accepted and utilized for tumor therapy. Considering the natural shortcomings (e.g., lack of an ideal photosensitizer and limited light penetration depth), lanthanide doped upconversion nanoparticles (Ln-doped UCNP), which can be excited with near-infrared light (NIR) for UV/visible/NIR upconversion luminescence (UCL) emissions, show great potential for augmenting biological treatment with PDT for solid tumors and for visual bioimaging of disease lesions. This review summarizes the basic concepts and important influence factors on PDT, the optimized construction of UCNP-based photosensitizer (UCNP-PS) systems, and some representative examples of UCNP-based PDT (UCPDT) applications in combination with other traditional therapy methods, such as chemotherapy, radiotherapy, photothermal therapy (PIT) and gene therapy. This review will provide guidance for the design and fabrication of future new UCNP-based nanocomposites for synergistic UC-PDT therapy. (C) 2017 Elsevier B.V. All rights reserved.
Keyword	Photodynamic therapy Upconversion nanoparticles Photosensitizers UCNP-based PDT Synergistic therapy
DOI	10.1016/j.ccr.2017.09.006
Language	英语
WOS Research Area	Chemistry
Publisher	ELSEVIER SCIENCE SA
Citation statistics
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/27396
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Liu, Yanyan,Meng, Xianfu,Bu, Wenbo. Upconversion-based photodynamic cancer therapy[J]. COORDINATION CHEMISTRY REVIEWS,2019,379:82.
APA	Liu, Yanyan,Meng, Xianfu,&Bu, Wenbo.(2019).Upconversion-based photodynamic cancer therapy.COORDINATION CHEMISTRY REVIEWS,379,82.
MLA	Liu, Yanyan,et al."Upconversion-based photodynamic cancer therapy".COORDINATION CHEMISTRY REVIEWS 379(2019):82.

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