Self-Assembled Copper Amino Acid Nanoparticles for in Situ Glutathione "AND" H2O2 Sequentially Triggered Chemodynamic Therapy

doi:10.1021/jacs.8b08714

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	Self-Assembled Copper Amino Acid Nanoparticles for in Situ Glutathione "AND" H2O2 Sequentially Triggered Chemodynamic Therapy
	Ma, Baojin; Wang, Shu; Liu, Feng; Zhang, Shan; Duan, Jiazhi; Li, Zhao; Kong, Ying; Sang, Yuanhua; Liu, Hong; Bu, Wenbo; Li, Linlin
	2019-01-16
Source Publication	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
ISSN	0002-7863
Volume	141 Issue:2 Pages:849
Subtype	Article
Abstract	Nanoformulations that can respond to the specific tumor microenvironment (TME), such as a weakly acidic pH, low oxygen, and high glutathione (GSH), show promise for killing cancer cells with minimal invasiveness and high specificity. In this study, we demonstrate self-assembled copper-amino acid mercaptide nanoparticles (Cu-Cys NPs) for in situ glutathione-activated and H2O2-reinforced chemodynamic therapy for drug resistant breast cancer. After endocytosis into tumor cells, the Cu-Cys NPs could first react with local GSH, induce GSH depletion, and reduce Cu2+ to Cu+. Subsequently, the generated Cu+ would react with local H2O2 to generate toxic hydroxyl radicals (center dot OH) via a Fenton-like reaction, which has a fast reaction rate in the weakly acidic TME, that are responsible for tumor-cell apoptosis. Due to the high GSH and H2O2 concentration in tumor cells, which sequentially triggers the redox reactions, Cu-Cys NPs exhibited relatively high cytotoxicity to cancer cells, whereas normal cells were left alive. The in vivo results also proved that Cu-Cys NPs efficiently inhibited drug-resistant breast cancer without causing obvious systemic toxicity. As a novel copper mercaptide nanoformulation responsive to the TME, these Cu-Cys NPs may have great potential in chemodynamic cancer therapy.
DOI	10.1021/jacs.8b08714
Language	英语
WOS Research Area	Chemistry
Publisher	AMER CHEMICAL SOC
Citation statistics
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/27393
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Ma, Baojin,Wang, Shu,Liu, Feng,et al. Self-Assembled Copper Amino Acid Nanoparticles for in Situ Glutathione "AND" H2O2 Sequentially Triggered Chemodynamic Therapy[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2019,141(2):849.
APA	Ma, Baojin.,Wang, Shu.,Liu, Feng.,Zhang, Shan.,Duan, Jiazhi.,...&Li, Linlin.(2019).Self-Assembled Copper Amino Acid Nanoparticles for in Situ Glutathione "AND" H2O2 Sequentially Triggered Chemodynamic Therapy.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,141(2),849.
MLA	Ma, Baojin,et al."Self-Assembled Copper Amino Acid Nanoparticles for in Situ Glutathione "AND" H2O2 Sequentially Triggered Chemodynamic Therapy".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 141.2(2019):849.

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