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Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reactions
Tang, Zhongmin; Liu, Yanyan; He, Mingyuan; Bu, Wenbo
2019-01-21
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
Volume58Issue:4Pages:946
SubtypeReview
AbstractTailored to the specific tumour microenvironment, which involves acidity and the overproduction of hydrogen peroxide, advanced nanotechnology has been introduced to generate the hydroxyl radical ((OH)-O-.) primarily for tumour chemodynamic therapy (CDT) through the Fenton and Fenton-like reactions. Numerous studies have investigated the enhancement of CDT efficiency, primarily the increase in the amount of (OH)-O-. generated. Notably, various strategies based on the Fenton reaction have been employed to enhance (OH)-O-. generation, including nanomaterials selection, modulation of the reaction environment, and external energy fields stimulation, which are discussed systematically in this Minireview. Furthermore, the potential challenges and the methods used to facilitate CDT effectiveness are also presented to support this cutting-edge research area.
Keywordchemodynamic therapy external energy fields Fenton reaction nanomaterials selection reaction environment
DOI10.1002/anie.201805664
Language英语
WOS Research AreaChemistry
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:282[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27390
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Tang, Zhongmin,Liu, Yanyan,He, Mingyuan,et al. Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reactions[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019,58(4):946.
APA Tang, Zhongmin,Liu, Yanyan,He, Mingyuan,&Bu, Wenbo.(2019).Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reactions.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,58(4),946.
MLA Tang, Zhongmin,et al."Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reactions".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58.4(2019):946.
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