SIC OpenIR
Micro/Nanometer-Structured Scaffolds for Regeneration of Both Cartilage and Subchondral Bone
Deng, Cuijun; Lin, Rongcai; Zhang, Meng; Qin, Chen; Yao, Qingqiang; Wang, Liming; Chang, Jiang; Wu, Chengtie
2019-01-24
Source PublicationADVANCED FUNCTIONAL MATERIALS
ISSN1616-301X
Volume29Issue:4
SubtypeArticle
AbstractTreatment of osteochondral defects remains a great challenge in clinical practice because cartilage and subchondral bone possess significantly different physiological properties. In this study, the controlled surface micro/nanometer structure of bioactive scaffolds in a combination of biomaterial chemistry is harnessed to address this issue. Model bioactive biomaterials, bredigite (BRT) scaffolds, with controlled surface micro/nanostructure are successfully fabricated by combining 3D printing with a hydrothermal process. It is found that the growth of micro/nano-calcium phosphate crystals on the surface of BRT scaffolds notably enhances their compressive strength by healing the microcracks on the strut surface. The micro/nanostructured surface distinctly facilitates the spread and differentiation of chondrocytes by activating integrin alpha vb1 and alpha 5b1 heterodimers, regulates cell morphology, and promotes osteogenic differentiation of rabbit bone marrow stromal cells (rBMSCs) through the synergetic effect of integrin alpha 5b1 and RhoA, in which the microrod surface demonstrates the highest stimulatory effect on the differentiation of chondrocytes and rBMSCs. The in vivo study shows that the micro/nanostructured surface of the 3D printed scaffolds obviously promotes the regeneration of both cartilage and subchondral bone tissues. This study suggests that the construction of controlled micro/nanostructured surface in porous 3D scaffolds offers a smart strategy to induce bilineage bioactivities for osteochondral regeneration.
Keyword3D printing cartilage regeneration micro/nanometer structure osteochondral regeneration osteogenic differentiation
DOI10.1002/adfm.201806068
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27385
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Deng, Cuijun,Lin, Rongcai,Zhang, Meng,et al. Micro/Nanometer-Structured Scaffolds for Regeneration of Both Cartilage and Subchondral Bone[J]. ADVANCED FUNCTIONAL MATERIALS,2019,29(4).
APA Deng, Cuijun.,Lin, Rongcai.,Zhang, Meng.,Qin, Chen.,Yao, Qingqiang.,...&Wu, Chengtie.(2019).Micro/Nanometer-Structured Scaffolds for Regeneration of Both Cartilage and Subchondral Bone.ADVANCED FUNCTIONAL MATERIALS,29(4).
MLA Deng, Cuijun,et al."Micro/Nanometer-Structured Scaffolds for Regeneration of Both Cartilage and Subchondral Bone".ADVANCED FUNCTIONAL MATERIALS 29.4(2019).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Deng, Cuijun]'s Articles
[Lin, Rongcai]'s Articles
[Zhang, Meng]'s Articles
Baidu academic
Similar articles in Baidu academic
[Deng, Cuijun]'s Articles
[Lin, Rongcai]'s Articles
[Zhang, Meng]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Deng, Cuijun]'s Articles
[Lin, Rongcai]'s Articles
[Zhang, Meng]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.