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Lithium-containing biomaterials stimulate bone marrow stromal cell-derived exosomal miR-130a secretion to promote angiogenesis
Liu, Lu; Liu, Yaqin; Feng, Chun; Chang, Jiang; Fu, Runqing; Wu, Tingting; Yu, Fei; Wang, Xiaoting; Xia, Lunguo; Wu, Chengtie; Fang, Bing
2019-02-01
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume192Pages:523
SubtypeArticle
AbstractThe chemical signals of biomaterials could influence bone marrow stromal cells (BMSCs)-endothelial cells (ECs) communication during vascularized bone regeneration. However, the underlying mechanisms still remain unknown. Exosomes, a series of extracellular vesicles, have recently emerged as potential paracrine mediators in cell-cell communication. However, whether exosomes and exosomal microRNAs (miRNAs) are involved in the chemical signals of biomaterials-modulated BMSCs-ECs communication are unknown. Hence, in the present study, a model Li-incorporated bioactive glass ceramic (Li-BGC) was applied to explore the chemical signals of biomaterials mediated cell-cell communication between BMSCs and ECs. Our results showed that Li-BGC directly promoted the pro-angiogenic capability of HUVECs in vitro and new blood vessel ingrowth in vivo. Moreover, Li-BGC activated Wnt/beta-catenin, AKT and NF-kappa B signaling pathways, while AKT signaling pathway might function as the upstream of Wnt/beta-catenin and NF-kappa B signaling pathways. More importantly, Li-BGC further facilitated the pro-angiogenic capacity of HUVECs by eliciting the expression of exosomal pro-angiogenic miR-130a in BMSCs-derived exosomes, which subsequently leading to the downregulation of PTEN protein and activation of AKT pathway, ultimately resulting in the elevated proliferation, migration and tube formation of endothelial cells, as well as the upregulated expression of pro-angiogenic genes. Our findings may provide new insights into the regulatory roles of the chemical signals of biomaterials in BMSCs-ECs communication via stimulating exosomal miR-130a secretion and PTEN/AKT signaling pathway in the angiogenic process of bone remodelling.
KeywordExosome MiR-130a/PTEN/AKT pathway Lithium Biomaterial Angiogenesis
DOI10.1016/j.biomaterials.2018.11.007
Language英语
WOS Research AreaEngineering ; Materials Science
PublisherELSEVIER SCI LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27369
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Liu, Lu,Liu, Yaqin,Feng, Chun,et al. Lithium-containing biomaterials stimulate bone marrow stromal cell-derived exosomal miR-130a secretion to promote angiogenesis[J]. BIOMATERIALS,2019,192:523.
APA Liu, Lu.,Liu, Yaqin.,Feng, Chun.,Chang, Jiang.,Fu, Runqing.,...&Fang, Bing.(2019).Lithium-containing biomaterials stimulate bone marrow stromal cell-derived exosomal miR-130a secretion to promote angiogenesis.BIOMATERIALS,192,523.
MLA Liu, Lu,et al."Lithium-containing biomaterials stimulate bone marrow stromal cell-derived exosomal miR-130a secretion to promote angiogenesis".BIOMATERIALS 192(2019):523.
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