SIC OpenIR
Chinese sesame stick-inspired nano-fibrous scaffolds for tumor therapy and skin tissue reconstruction
Yu, Qingqing; Han, Yiming; Tian, Tian; Zhou, Quan; Yi, Zhengfang; Chang, Jiang; Wu, Chengtie
2019-02-01
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume194Pages:25
SubtypeArticle
AbstractSurgery is a common treatment to remove the solid skin tumors. It is of great importance to eliminate the remaining tumor cells and achieve the simultaneous tissue reconstruction after surgery for improving life quality of cancer patients. Inspired by the designing strategy and fabrication method of Chinese sesame sticks, a Chinese sesame stick-like scaffold is developed by spin coating of CaCuSi4O10 nanoparticles (NPs) on the surface of electrospun fibers for tumor therapy and skin tissue reconstruction. The CaCuSi4O10 NPs can transform near infrared light energy into heat energy, showing the photothermal conversion efficiency of 33.8%. After coating of the CaCuSi4O10 NPs on the fibers, the prepared scaffolds exhibit the Chinese sesame stick-like structure and achieve bifunction with both tumor killing and skin tissue reconstruction capacities. The CaCuSi4O10 NPs endow the scaffolds with photothermal ablation potential to rapidly kill the in vitro tumor cells. Furthermore, Chinese sesame stick-like scaffolds effectively inhibit in vivo tumor growth at the early stage and accelerate healing of cancer surgery-caused wounds at the later stage in tumor-bearing mice. Additionally, the composite scaffolds promote chronic wound healing by stimulating in vivo angiogenesis and re-epithelization, harnessing locally release of bioactive Cu2+ and SiO44- ions from the CaCuSi4O10 NPs. Therefore, the Chinese sesame stick-inspired scaffolds may lay a solid foundation for clinical treatment of cancers and cancer surgery-induced tissue damage.
KeywordChinese sesame stick CaCuSi4O10 Scaffolds Tumor therapy Tissue reconstruction
DOI10.1016/j.biomaterials.2018.12.012
Language英语
WOS Research AreaEngineering ; Materials Science
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27366
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Yu, Qingqing,Han, Yiming,Tian, Tian,et al. Chinese sesame stick-inspired nano-fibrous scaffolds for tumor therapy and skin tissue reconstruction[J]. BIOMATERIALS,2019,194:25.
APA Yu, Qingqing.,Han, Yiming.,Tian, Tian.,Zhou, Quan.,Yi, Zhengfang.,...&Wu, Chengtie.(2019).Chinese sesame stick-inspired nano-fibrous scaffolds for tumor therapy and skin tissue reconstruction.BIOMATERIALS,194,25.
MLA Yu, Qingqing,et al."Chinese sesame stick-inspired nano-fibrous scaffolds for tumor therapy and skin tissue reconstruction".BIOMATERIALS 194(2019):25.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yu, Qingqing]'s Articles
[Han, Yiming]'s Articles
[Tian, Tian]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yu, Qingqing]'s Articles
[Han, Yiming]'s Articles
[Tian, Tian]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yu, Qingqing]'s Articles
[Han, Yiming]'s Articles
[Tian, Tian]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.