Nanocatalytic Tumor Therapy by Single-Atom Catalysts
Huo, Minfeng; Wang, Liying; Wang, Youwei; Chen, Yu; Shi, Jianlin
Source PublicationACS NANO
AbstractInitiating localized catalytic chemical reactions in tumor microenvironment (TME) can achieve appealing tumor-therapeutic efficacy concurrently with high specificity and desirable biosafety, which is mainly dependent on the high performance of biomedical nanocatalysts. This report demonstrates that PEGylated single-atom Fe-containing nanocatalysts (PSAF NCs) could effectively trigger the in situ tumor-specific Fenton reaction to generate abundant toxic hydroxyl radicals (center dot OH) selectively under the acidic TME. Based on density functional theory, it has been theoretically uncovered that the nanocatalysts could specifically catalyze the heterogeneous Fenton reaction via a proton-mediated H2O2-homolytic pathway. These generated radicals could not only lead to the apoptotic cell death of malignant tumors, but also induce the accumulation of lipid peroxides, causing tumor cell ferroptosis, which synergistically lead to an impressive tumor suppression outcome. In the meantime, the favorable biodegradability and biocompatibility of PSAF NCs also guarantee their desirable biosafety both in vivo and in vitro.
Keywordsingle-atom catalyst nanocatalytic medicine tumor nanotherapy heterogeneous Fenton reaction photothermal effect
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
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Cited Times:70[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Recommended Citation
GB/T 7714
Huo, Minfeng,Wang, Liying,Wang, Youwei,et al. Nanocatalytic Tumor Therapy by Single-Atom Catalysts[J]. ACS NANO,2019,13(2):2643.
APA Huo, Minfeng,Wang, Liying,Wang, Youwei,Chen, Yu,&Shi, Jianlin.(2019).Nanocatalytic Tumor Therapy by Single-Atom Catalysts.ACS NANO,13(2),2643.
MLA Huo, Minfeng,et al."Nanocatalytic Tumor Therapy by Single-Atom Catalysts".ACS NANO 13.2(2019):2643.
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