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CT/MRI-Guided Synergistic Radiotherapy and X-ray Inducible Photodynamic Therapy Using Tb-Doped Gd-W-Nanoscintillators
Yu, Xujiang; Liu, Xinyi; Wu, Weijie; Yang, Kai; Mao, Rihua; Ahmad, Farooq; Chen, Xiaoyuan; Li, Wanwan
2019-02-11
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
Volume58Issue:7Pages:2017
SubtypeArticle
AbstractThe use of X-rays instead of UV/Vis light to trigger photodynamic therapy, named X-ray inducible photodynamic therapy, holds tremendous promise due to a high penetration capacity in tissues and is worthy of in-depth study. In this study, a novel multifunctional nanoagent based on Merocyanine 540-coupled Gd-2(WO4)(3):Tb nanoscintillators and the vitalization of its abilities for dual-modal computed tomography and the magnetic-resonance-imaging-guided synergistic radio-/X-ray inducible photodynamic therapy of tumors is reported. Synergistic therapies show a higher tumor growth inhibition efficiency at a lower X-ray dose than radiotherapy alone. Through this proof-of-concept work, a way to tactfully understand and utilize nanoscintillators for cancer theranostics is shown.
Keywordcomputed tomography magnetic resonance imaging nanoscintillators radiotherapy X-ray inducible photodynamic therapy
DOI10.1002/anie.201812272
Language英语
WOS Research AreaChemistry
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:30[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27336
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Yu, Xujiang,Liu, Xinyi,Wu, Weijie,et al. CT/MRI-Guided Synergistic Radiotherapy and X-ray Inducible Photodynamic Therapy Using Tb-Doped Gd-W-Nanoscintillators[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019,58(7):2017.
APA Yu, Xujiang.,Liu, Xinyi.,Wu, Weijie.,Yang, Kai.,Mao, Rihua.,...&Li, Wanwan.(2019).CT/MRI-Guided Synergistic Radiotherapy and X-ray Inducible Photodynamic Therapy Using Tb-Doped Gd-W-Nanoscintillators.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,58(7),2017.
MLA Yu, Xujiang,et al."CT/MRI-Guided Synergistic Radiotherapy and X-ray Inducible Photodynamic Therapy Using Tb-Doped Gd-W-Nanoscintillators".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58.7(2019):2017.
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