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Mussel-Inspired Polydopamine Coating: A General Strategy To Enhance Osteogenic Differentiation and Osseointegration for Diverse Implants
Wang, Hui; Lin, Chucheng; Zhang, Xinran; Lin, Kaili; Wang, Xudong; Shen, Steve Guofang
2019-02-20
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume11Issue:7Pages:7615
SubtypeArticle
AbstractSurface modifications play an important role in endowing implant surface with excellent biocompatibility and bioactivity. Among the bioinspired surface modifications, the mussel-inspired polydopamine (PDA) has aroused great interest of researchers. Herein, we fabricated PDA on diverse implant surfaces, including biopolymer, biometal, and bioceramic. Then the effects of PDA coating on cell responsive behaviors in vitro and bone formation capacity in vivo were evaluated in detail. The results showed that PDA coating was fabricated on diverse samples surface successfully, which could significantly improve the hydrophilicity of different material surfaces. Furthermore, the results indicated that PDA coating exerted direct enhancing on the adhesion, proliferation and osteogenic differentiation of bone marrow derived mesenchymal stromal cells (BMSCs) through FAK and p38 signaling pathways. During the process, the focal adhesion protein expression and osteogenic-related genes expression level (e.g., ALP, BMP2, BSP, and OPN) were considerably upregulated. Most importantly, the in vivo study confirmed that PDA coating remarkably accelerated new bone formation and enhanced osseointegration performance. Our study uncovered the biological responses stimulated by PDA coating to make a better understanding of cell/tissue-PDA interactions and affirmed that PDA, a bioinspired polymer, has great potential as a candidate and functional bioactive coating medium in bone regeneration and orthopedic application.
Keywordpolydopamine coating osteogenic differentiation osseointegration cell signaling pathway
DOI10.1021/acsami.8b21558
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:25[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27324
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Wang, Hui,Lin, Chucheng,Zhang, Xinran,et al. Mussel-Inspired Polydopamine Coating: A General Strategy To Enhance Osteogenic Differentiation and Osseointegration for Diverse Implants[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(7):7615.
APA Wang, Hui,Lin, Chucheng,Zhang, Xinran,Lin, Kaili,Wang, Xudong,&Shen, Steve Guofang.(2019).Mussel-Inspired Polydopamine Coating: A General Strategy To Enhance Osteogenic Differentiation and Osseointegration for Diverse Implants.ACS APPLIED MATERIALS & INTERFACES,11(7),7615.
MLA Wang, Hui,et al."Mussel-Inspired Polydopamine Coating: A General Strategy To Enhance Osteogenic Differentiation and Osseointegration for Diverse Implants".ACS APPLIED MATERIALS & INTERFACES 11.7(2019):7615.
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