SIC OpenIR
AlPcS-loaded gold nanobipyramids with high two-photon efficiency for photodynamic therapy in vivo
Wang, Jing; Zhuo, Xiaolu; Xiao, Xiao; Mao, Rihua; Wang, Yong; Wang, Jianfang; Liu, Jun
2019-02-21
Source PublicationNANOSCALE
ISSN2040-3364
Volume11Issue:7Pages:3386
SubtypeArticle
AbstractRecent years have witnessed significant progress in the field of two-photon-activated photodynamic therapy (TP-PDT). However, traditional photosensitizer (PS)-based TP-PDT remains a critical challenge in clinics due to its low two-photon absorption cross sections. Here, we propose that the therapeutic activity of the current photosensitizer, sulfonated Al-phthalocyanine (AlPcS), can be efficiently excited via plasmonic-resonance energy transfer from the two-photon excited gold nanobipyramids (GBPs) and further generates cytotoxic singlet oxygen for cancer eradication. GBPs possess large two-photon absorption cross sections, excellent photostability, and biocompatibility, which can be used for a high two-photon light-harvesting material in biomedical applications. We compared the in vitro and in vivo capabilities of AlPcS-loaded GBPs as a TP-PDT agent for theranostic applications by benchmarking them against those of the extensively studied gold nanospheres (GNS) and nanorods (GNR). Although all these Au nanostructures could cause enhanced PS two-photon excitation fluorescence and improved singlet oxygen generation capability via the plasmonic resonance-energy transfer process, GBP-AlPcS exhibited the highest two-photon efficiency for photodynamic therapy. Remarkably, in vivo experiment results clearly indicated that the GBP-AlPcS caused efficient suppression of tumor growth and minimal adverse effects on orthotopic A549 human lung tumor xenografts. The system presents great efficiency in improving the treatment depth and precision of traditional photodynamic therapy.
DOI10.1039/c9nr00004f
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27321
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Wang, Jing,Zhuo, Xiaolu,Xiao, Xiao,et al. AlPcS-loaded gold nanobipyramids with high two-photon efficiency for photodynamic therapy in vivo[J]. NANOSCALE,2019,11(7):3386.
APA Wang, Jing.,Zhuo, Xiaolu.,Xiao, Xiao.,Mao, Rihua.,Wang, Yong.,...&Liu, Jun.(2019).AlPcS-loaded gold nanobipyramids with high two-photon efficiency for photodynamic therapy in vivo.NANOSCALE,11(7),3386.
MLA Wang, Jing,et al."AlPcS-loaded gold nanobipyramids with high two-photon efficiency for photodynamic therapy in vivo".NANOSCALE 11.7(2019):3386.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Jing]'s Articles
[Zhuo, Xiaolu]'s Articles
[Xiao, Xiao]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Jing]'s Articles
[Zhuo, Xiaolu]'s Articles
[Xiao, Xiao]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Jing]'s Articles
[Zhuo, Xiaolu]'s Articles
[Xiao, Xiao]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.