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3D printing of a lithium-calcium-silicate crystal bioscaffold with dual bioactivities for osteochondral interface reconstruction
Chen, Lei; Deng, Cuijun; Li, Jiayi; Yao, Qingqiang; Chang, Jiang; Wang, Liming; Wu, Chengtie
2019-03-01
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume196Pages:138
SubtypeArticle
AbstractIt is difficult to achieve self-healing outcoming for the osteochondral defects caused by degenerative diseases. The simultaneous regeneration of both cartilage and subchondral bone tissues is an effective therapeutic strategy for osteochondral defects. However, it is challenging to design a single type of bioscaffold with suitable ionic components and beneficial osteo/chondral-stimulation ability for regeneration of osteochondral defects. In this study, we successfully synthesized a pure-phase lithium calcium silicate (Li2Ca4Si4O13, L2C4S4) bioceramic by a sol-gel method, and further prepared L2C4S4 scaffolds by using a 3D-printing method. The compressive strength of L2C4S4 scaffolds could be well controlled in the range of 15-40 MPa when pore size varied from 170 to 400 gm. L2C4S4 scaffolds have been demonstrated to possess controlled biodegradability and good apatite-mineralization ability. At a certain concentration range, the ionic products from L2C4S4 significantly stimulated the proliferation and maturation of chondrocytes, as well as promoted the osteogenic differentiation of rBMSCs. L2C4S4 scaffolds simultaneously promoted the regeneration of both cartilage and subchondral bone as compared to pure beta-TCP scaffolds in rabbit osteochondral defects. These findings suggest that 3D-printed L2C4S4 scaffolds with such specific ionic combination, high mechanical strength and good degradability as well as dual bioactivities, represent a promising biomaterial for osteochondral interface reconstruction. (C) 2018 Elsevier Ltd. All rights reserved.
KeywordScaffolds Lithium calcium silicate Dual bioactivity Osteochondral reconstruction Tissue engineering
DOI10.1016/j.biomaterials.2018.04.005
Language英语
WOS Research AreaEngineering ; Materials Science
PublisherELSEVIER SCI LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27309
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Chen, Lei,Deng, Cuijun,Li, Jiayi,et al. 3D printing of a lithium-calcium-silicate crystal bioscaffold with dual bioactivities for osteochondral interface reconstruction[J]. BIOMATERIALS,2019,196:138.
APA Chen, Lei.,Deng, Cuijun.,Li, Jiayi.,Yao, Qingqiang.,Chang, Jiang.,...&Wu, Chengtie.(2019).3D printing of a lithium-calcium-silicate crystal bioscaffold with dual bioactivities for osteochondral interface reconstruction.BIOMATERIALS,196,138.
MLA Chen, Lei,et al."3D printing of a lithium-calcium-silicate crystal bioscaffold with dual bioactivities for osteochondral interface reconstruction".BIOMATERIALS 196(2019):138.
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