Nano Textured PEEK Surface for Enhanced Osseointegration

doi:10.1021/acsbiomaterials.8b01425

SIC OpenIR

	Nano Textured PEEK Surface for Enhanced Osseointegration
	Ouyang, Liping; Chen, Meiling; Wang, Donghui; Lu, Tao; Wang, Heying; Meng, Fanhao; Yang, Yan; Ma, Jingzhi; Yeung, Kelvin W. K.; Liu, Xuanyong
	2019-03-01
Source Publication	ACS BIOMATERIALS SCIENCE & ENGINEERING
ISSN	2373-9878
Volume	5 Issue:3 Pages:1279
Subtype	Article
Abstract	Polyetheretherketone (PEEK) is widely used in orthopedic and dental applications because of its similar mechanical properties to those of natural bones. However, the inferior osseointegration and bioinertness hamper the clinic application. The surface texture of biomaterials plays an essential role in controlling cell differentiation through affecting the cell-generated physical forces, thus improving the osseointegration of the substrate. In this work, argon PIII and subsequently hydrogen peroxide treatment are applied to construct the nanostructure on the PEEK surface. The in vitro results show that the cell adhesion, collagen secretion, and extracellular matrix (ECM) deposition can be enhanced on both nanostructured surfaces. The in vivo tests exhibit that the surface fabricated by physical-chemical treatment is more favorable for fibrous tissue filtration inhibition and osseointegration than that fabricated by argon PIII only. This work provides a candidate approach for improving the osseointegration ability of PEEK implant by constructing the nanostructure on its surface, which paves the way of applying PEEK in orthopedic and dental applications.
Keyword	polyetheretherketone nanostructure osseointegration
DOI	10.1021/acsbiomaterials.8b01425
Language	英语
WOS Research Area	Materials Science
Publisher	AMER CHEMICAL SOC
Citation statistics
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/27302
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Ouyang, Liping,Chen, Meiling,Wang, Donghui,et al. Nano Textured PEEK Surface for Enhanced Osseointegration[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2019,5(3):1279.
APA	Ouyang, Liping.,Chen, Meiling.,Wang, Donghui.,Lu, Tao.,Wang, Heying.,...&Liu, Xuanyong.(2019).Nano Textured PEEK Surface for Enhanced Osseointegration.ACS BIOMATERIALS SCIENCE & ENGINEERING,5(3),1279.
MLA	Ouyang, Liping,et al."Nano Textured PEEK Surface for Enhanced Osseointegration".ACS BIOMATERIALS SCIENCE & ENGINEERING 5.3(2019):1279.

Files in This Item:
There are no files associated with this item.

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Institution:
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh

中国科学院上海硅酸盐研究所机构知识库