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Inorganic Nanoshell-Stabilized Liquid Metal for Targeted Photonanomedicine in NIR-II Biowindow
Zhu, Piao; Gao, Shanshan; Lin, Han; Lu, Xiangyu; Yang, Bowen; Zhang, Linlin; Chen, Yu; Shi, Jianlin
2019-03-01
Source PublicationNANO LETTERS
ISSN1530-6984
Volume19Issue:3Pages:2128
SubtypeArticle
AbstractGallium and gallium-based alloys, typical types of liquid metals with unique physiochemical properties, are emerging as a next generation of functional materials in versatile biomedical applications. However, the exploration of their biomedical performance is currently insufficient, and their intrinsic low oxidative resistance is a key factor blocking their further clinical translation. Herein, we report on the surface engineering of liquid metal-based nanoplatforms by an inorganic silica nanoshell based on a novel but facile sonochemical synthesis for highly efficient, targeted, and near-infrared (NIR)-triggered photothermal tumor hyperthermia in the NIR-II biowindow. The inorganic silica-shell engineering of liquid metal significantly enhances the photothermal performance of the liquid metal core as reflected by enhanced NIR absorption, improved photothermal stability by oxidation protection, and abundant surface chemistry for surface-targeted engineering to achieve enhanced tumor accumulation. Systematic in vitro cell-level evaluation and in vivo tumor xenograft assessment demonstrate that (Arg-Gly-Asp) RGD-targeted and silica-coated nanoscale liquid metal substantially induces phototriggered cancer-cell death and photothermal tumor eradication, accompanied by high in vivo biocompatibility and easy excretion out of the body. This work provides the first paradigm for surface-inorganic engineering of liquid metal-based nanoplatforms for achieving multiple desirable therapeutic performances, especially for combating cancer.
KeywordLiquid metal photothermal therapy NIR-II targeted nanomedicine cancer
DOI10.1021/acs.nanolett.9b00364
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
PublisherAMER CHEMICAL SOC
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Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27300
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Zhu, Piao,Gao, Shanshan,Lin, Han,et al. Inorganic Nanoshell-Stabilized Liquid Metal for Targeted Photonanomedicine in NIR-II Biowindow[J]. NANO LETTERS,2019,19(3):2128.
APA Zhu, Piao.,Gao, Shanshan.,Lin, Han.,Lu, Xiangyu.,Yang, Bowen.,...&Shi, Jianlin.(2019).Inorganic Nanoshell-Stabilized Liquid Metal for Targeted Photonanomedicine in NIR-II Biowindow.NANO LETTERS,19(3),2128.
MLA Zhu, Piao,et al."Inorganic Nanoshell-Stabilized Liquid Metal for Targeted Photonanomedicine in NIR-II Biowindow".NANO LETTERS 19.3(2019):2128.
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