Inorganic Nanoshell-Stabilized Liquid Metal for Targeted Photonanomedicine in NIR-II Biowindow

doi:10.1021/acs.nanolett.9b00364

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	Inorganic Nanoshell-Stabilized Liquid Metal for Targeted Photonanomedicine in NIR-II Biowindow
	Zhu, Piao; Gao, Shanshan; Lin, Han; Lu, Xiangyu; Yang, Bowen; Zhang, Linlin; Chen, Yu; Shi, Jianlin
	2019-03-01
Source Publication	NANO LETTERS
ISSN	1530-6984
Volume	19 Issue:3 Pages:2128
Subtype	Article
Abstract	Gallium and gallium-based alloys, typical types of liquid metals with unique physiochemical properties, are emerging as a next generation of functional materials in versatile biomedical applications. However, the exploration of their biomedical performance is currently insufficient, and their intrinsic low oxidative resistance is a key factor blocking their further clinical translation. Herein, we report on the surface engineering of liquid metal-based nanoplatforms by an inorganic silica nanoshell based on a novel but facile sonochemical synthesis for highly efficient, targeted, and near-infrared (NIR)-triggered photothermal tumor hyperthermia in the NIR-II biowindow. The inorganic silica-shell engineering of liquid metal significantly enhances the photothermal performance of the liquid metal core as reflected by enhanced NIR absorption, improved photothermal stability by oxidation protection, and abundant surface chemistry for surface-targeted engineering to achieve enhanced tumor accumulation. Systematic in vitro cell-level evaluation and in vivo tumor xenograft assessment demonstrate that (Arg-Gly-Asp) RGD-targeted and silica-coated nanoscale liquid metal substantially induces phototriggered cancer-cell death and photothermal tumor eradication, accompanied by high in vivo biocompatibility and easy excretion out of the body. This work provides the first paradigm for surface-inorganic engineering of liquid metal-based nanoplatforms for achieving multiple desirable therapeutic performances, especially for combating cancer.
Keyword	Liquid metal photothermal therapy NIR-II targeted nanomedicine cancer
DOI	10.1021/acs.nanolett.9b00364
Language	英语
WOS Research Area	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
Publisher	AMER CHEMICAL SOC
Citation statistics
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/27300
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Zhu, Piao,Gao, Shanshan,Lin, Han,et al. Inorganic Nanoshell-Stabilized Liquid Metal for Targeted Photonanomedicine in NIR-II Biowindow[J]. NANO LETTERS,2019,19(3):2128.
APA	Zhu, Piao.,Gao, Shanshan.,Lin, Han.,Lu, Xiangyu.,Yang, Bowen.,...&Shi, Jianlin.(2019).Inorganic Nanoshell-Stabilized Liquid Metal for Targeted Photonanomedicine in NIR-II Biowindow.NANO LETTERS,19(3),2128.
MLA	Zhu, Piao,et al."Inorganic Nanoshell-Stabilized Liquid Metal for Targeted Photonanomedicine in NIR-II Biowindow".NANO LETTERS 19.3(2019):2128.

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