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Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy
Fan, Wenpei; Lu, Nan; Shen, Zheyu; Tang, Wei; Shen, Bo; Cui, Zhaowen; Shan, Lingling; Yang, Zhen; Wang, Zhantong; Jacobson, Orit; Zhou, Zijian; Liu, Yijing; Hu, Ping; Yang, Weijing; Song, Jibin; Zhang, Yang; Zhang, Liwen; Khashab, Niveen M.; Aronova, Maria A.; Lu, Guangming; Chen, Xiaoyuan
2019-03-18
Source PublicationNATURE COMMUNICATIONS
ISSN2041-1723
Volume10
SubtypeArticle
AbstractThe success of radiotherapy relies on tumor-specific delivery of radiosensitizers to attenuate hypoxia resistance. Here we report an ammonia-assisted hot water etching strategy for the generic synthesis of a library of small-sized (sub-50 nm) hollow mesoporous organosilica nanoparticles (HMONs) with mono, double, triple, and even quadruple framework hybridization of diverse organic moieties by changing only the introduced bissilylated organosilica precursors. The biodegradable thioether-hybridized HMONs are chosen for efficient co-delivery of tert-butyl hydroperoxide (TBHP) and iron pentacarbonyl (Fe(CO)(5)). Distinct from conventional RT, radiodynamic therapy (RDT) is developed by taking advantage of X-ray-activated peroxy bond cleavage within TBHP to generate center dot OH, which can further attack Fe (CO)(5) to release CO molecules for gas therapy. Detailed in vitro and in vivo studies reveal the X-ray-activated cascaded release of center dot OH and CO molecules from TBHP/Fe(CO)(5) co-loaded PEGylated HMONs without reliance on oxygen, which brings about remarkable destructive effects against both normoxic and hypoxic cancers.
DOI10.1038/s41467-019-09158-1
Language英语
WOS Research AreaScience & Technology - Other Topics
PublisherNATURE PUBLISHING GROUP
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27269
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Fan, Wenpei,Lu, Nan,Shen, Zheyu,et al. Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy[J]. NATURE COMMUNICATIONS,2019,10.
APA Fan, Wenpei.,Lu, Nan.,Shen, Zheyu.,Tang, Wei.,Shen, Bo.,...&Chen, Xiaoyuan.(2019).Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy.NATURE COMMUNICATIONS,10.
MLA Fan, Wenpei,et al."Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy".NATURE COMMUNICATIONS 10(2019).
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