Improved antibacterial properties of collagen I/hyaluronic acid/quaternized chitosan multilayer modified titanium coatings with both contact-killing and release-killing functions

doi:10.1039/c8tb02425a

SIC OpenIR

	Improved antibacterial properties of collagen I/hyaluronic acid/quaternized chitosan multilayer modified titanium coatings with both contact-killing and release-killing functions
	Ao, Haiyong; Yang, Shengbing; Nie, Bin'en; Fan, Qiming; Zhang, Quanchao; Zong, Jiajia; Guo, Shengrong; Zheng, Xuebin; Tang, Tingting
	2019-03-21
Source Publication	JOURNAL OF MATERIALS CHEMISTRY B
ISSN	2050-750X
Volume	7 Issue:11 Pages:1951
Subtype	Article
Abstract	Implant infection is one of the most severe complications after orthopedic surgery. The construction of an antibacterial coating on orthopedic implants with release-killing or contact-killing is one of the most efficient strategies to prevent implant-related infections. Here we reported a hydroxypropyltrimethyl ammonium chloride chitosan (HACC) based multilayer modified plasma-sprayed porous titanium coating generated via the layer-by-layer covalent-immobilized method. We demonstrated that the multilayer coating inhibited the colonization and biofilm formation of several bacterial strains, including Staphylococcus aureus (ATCC 25923), methicillin-resistant Staphylococcus aureus (MSRA, ATCC 43300) and clinical isolates of methicillin-resistant Staphylococcus epidermidis (MRSE 287), in vitro. HACC in the multilayer was released slowly with the degradation of the coating under the action of collagenase, further killing the planktonic bacteria, while the remaining HACC could kill the colonized bacteria. In a rat model of femur implants, the HACC-based multilayer-modified TCs effectively controlled the infection caused by MRSA and prevented bone destruction. Therefore, the HACC-based multilayer modified TCs with multiple antimicrobial properties could be a new potential ideal surface modification strategy to prevent implant associated infections.
DOI	10.1039/c8tb02425a
Language	英语
WOS Research Area	Materials Science
Publisher	ROYAL SOC CHEMISTRY
Citation statistics
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/27264
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Ao, Haiyong,Yang, Shengbing,Nie, Bin'en,et al. Improved antibacterial properties of collagen I/hyaluronic acid/quaternized chitosan multilayer modified titanium coatings with both contact-killing and release-killing functions[J]. JOURNAL OF MATERIALS CHEMISTRY B,2019,7(11):1951.
APA	Ao, Haiyong.,Yang, Shengbing.,Nie, Bin'en.,Fan, Qiming.,Zhang, Quanchao.,...&Tang, Tingting.(2019).Improved antibacterial properties of collagen I/hyaluronic acid/quaternized chitosan multilayer modified titanium coatings with both contact-killing and release-killing functions.JOURNAL OF MATERIALS CHEMISTRY B,7(11),1951.
MLA	Ao, Haiyong,et al."Improved antibacterial properties of collagen I/hyaluronic acid/quaternized chitosan multilayer modified titanium coatings with both contact-killing and release-killing functions".JOURNAL OF MATERIALS CHEMISTRY B 7.11(2019):1951.

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