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Improved antibacterial properties of collagen I/hyaluronic acid/quaternized chitosan multilayer modified titanium coatings with both contact-killing and release-killing functions
Ao, Haiyong; Yang, Shengbing; Nie, Bin'en; Fan, Qiming; Zhang, Quanchao; Zong, Jiajia; Guo, Shengrong; Zheng, Xuebin; Tang, Tingting
2019-03-21
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Volume7Issue:11Pages:1951
SubtypeArticle
AbstractImplant infection is one of the most severe complications after orthopedic surgery. The construction of an antibacterial coating on orthopedic implants with release-killing or contact-killing is one of the most efficient strategies to prevent implant-related infections. Here we reported a hydroxypropyltrimethyl ammonium chloride chitosan (HACC) based multilayer modified plasma-sprayed porous titanium coating generated via the layer-by-layer covalent-immobilized method. We demonstrated that the multilayer coating inhibited the colonization and biofilm formation of several bacterial strains, including Staphylococcus aureus (ATCC 25923), methicillin-resistant Staphylococcus aureus (MSRA, ATCC 43300) and clinical isolates of methicillin-resistant Staphylococcus epidermidis (MRSE 287), in vitro. HACC in the multilayer was released slowly with the degradation of the coating under the action of collagenase, further killing the planktonic bacteria, while the remaining HACC could kill the colonized bacteria. In a rat model of femur implants, the HACC-based multilayer-modified TCs effectively controlled the infection caused by MRSA and prevented bone destruction. Therefore, the HACC-based multilayer modified TCs with multiple antimicrobial properties could be a new potential ideal surface modification strategy to prevent implant associated infections.
DOI10.1039/c8tb02425a
Language英语
WOS Research AreaMaterials Science
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27264
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Ao, Haiyong,Yang, Shengbing,Nie, Bin'en,et al. Improved antibacterial properties of collagen I/hyaluronic acid/quaternized chitosan multilayer modified titanium coatings with both contact-killing and release-killing functions[J]. JOURNAL OF MATERIALS CHEMISTRY B,2019,7(11):1951.
APA Ao, Haiyong.,Yang, Shengbing.,Nie, Bin'en.,Fan, Qiming.,Zhang, Quanchao.,...&Tang, Tingting.(2019).Improved antibacterial properties of collagen I/hyaluronic acid/quaternized chitosan multilayer modified titanium coatings with both contact-killing and release-killing functions.JOURNAL OF MATERIALS CHEMISTRY B,7(11),1951.
MLA Ao, Haiyong,et al."Improved antibacterial properties of collagen I/hyaluronic acid/quaternized chitosan multilayer modified titanium coatings with both contact-killing and release-killing functions".JOURNAL OF MATERIALS CHEMISTRY B 7.11(2019):1951.
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