Artificial anaerobic cell dormancy for tumor gaseous microenvironment regulation therapy

doi:10.1016/j.biomaterials.2019.02.007

SIC OpenIR

	Artificial anaerobic cell dormancy for tumor gaseous microenvironment regulation therapy
	Chen, Chen; Su, Weiwei; Liu, Yanyan; Zhang, Jiawen; Zuo, Changjing; Yao, Zhenwei; Bu, Wenbo
	2019-04-01
Source Publication	BIOMATERIALS
ISSN	0142-9612
Volume	200 Pages:48
Subtype	Article
Abstract	Oxygen is known as an irreplaceable gas in the lives of most eukaryotic cells, yet researchers underestimate its importance, as in the case in many studies of tumors. The variable oxygen content of malignant solid tumors increases the difficulty of treatment. Thus, it could be reasonably inferred that the tumor oxygen micro environment, if efficiently and completely regulated, could bring certain changes to existing therapies. Based on this speculation, an acid-responsive, oxygen-scavenging and anaerobic-sensitizing nanoparticle was designed to regulate the oxygen level of solid tumor by creating an artificial anaerobic environment in our study. The Mg2Si core, which acted as a deoxygenating agent, was able to consume tumor oxygen and cause cell dormancy, while the incorporated hydrophobic tirapazamin (TPZ) helped to kill the now-dormant tumor cells. This simple and nontoxic nanoparticle achieved controllable factitious anaerobic circumstance in solid tumor for the first time, displaying the considerable potential and promising application of tumor gaseous microenvironment regulation therapy.
Keyword	Gaseous microenvironment regulation Cell dormancy Hypoxia Anaerobic Controlled drug release
DOI	10.1016/j.biomaterials.2019.02.007
Language	英语
WOS Research Area	Engineering ; Materials Science
Publisher	ELSEVIER SCI LTD
Citation statistics	Cited Times:3[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/27228
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Chen, Chen,Su, Weiwei,Liu, Yanyan,et al. Artificial anaerobic cell dormancy for tumor gaseous microenvironment regulation therapy[J]. BIOMATERIALS,2019,200:48.
APA	Chen, Chen.,Su, Weiwei.,Liu, Yanyan.,Zhang, Jiawen.,Zuo, Changjing.,...&Bu, Wenbo.(2019).Artificial anaerobic cell dormancy for tumor gaseous microenvironment regulation therapy.BIOMATERIALS,200,48.
MLA	Chen, Chen,et al."Artificial anaerobic cell dormancy for tumor gaseous microenvironment regulation therapy".BIOMATERIALS 200(2019):48.

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