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Artificial anaerobic cell dormancy for tumor gaseous microenvironment regulation therapy
Chen, Chen; Su, Weiwei; Liu, Yanyan; Zhang, Jiawen; Zuo, Changjing; Yao, Zhenwei; Bu, Wenbo
2019-04-01
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume200Pages:48
SubtypeArticle
AbstractOxygen is known as an irreplaceable gas in the lives of most eukaryotic cells, yet researchers underestimate its importance, as in the case in many studies of tumors. The variable oxygen content of malignant solid tumors increases the difficulty of treatment. Thus, it could be reasonably inferred that the tumor oxygen micro environment, if efficiently and completely regulated, could bring certain changes to existing therapies. Based on this speculation, an acid-responsive, oxygen-scavenging and anaerobic-sensitizing nanoparticle was designed to regulate the oxygen level of solid tumor by creating an artificial anaerobic environment in our study. The Mg2Si core, which acted as a deoxygenating agent, was able to consume tumor oxygen and cause cell dormancy, while the incorporated hydrophobic tirapazamin (TPZ) helped to kill the now-dormant tumor cells. This simple and nontoxic nanoparticle achieved controllable factitious anaerobic circumstance in solid tumor for the first time, displaying the considerable potential and promising application of tumor gaseous microenvironment regulation therapy.
KeywordGaseous microenvironment regulation Cell dormancy Hypoxia Anaerobic Controlled drug release
DOI10.1016/j.biomaterials.2019.02.007
Language英语
WOS Research AreaEngineering ; Materials Science
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27228
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Chen, Chen,Su, Weiwei,Liu, Yanyan,et al. Artificial anaerobic cell dormancy for tumor gaseous microenvironment regulation therapy[J]. BIOMATERIALS,2019,200:48.
APA Chen, Chen.,Su, Weiwei.,Liu, Yanyan.,Zhang, Jiawen.,Zuo, Changjing.,...&Bu, Wenbo.(2019).Artificial anaerobic cell dormancy for tumor gaseous microenvironment regulation therapy.BIOMATERIALS,200,48.
MLA Chen, Chen,et al."Artificial anaerobic cell dormancy for tumor gaseous microenvironment regulation therapy".BIOMATERIALS 200(2019):48.
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