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Grape Seed-Inspired Smart Hydrogel Scaffolds for Melanoma Therapy and Wound Healing
Ma, Hongshi; Zhou, Quan; Chang, Jiang; Wu, Chengtie
2019-04-01
Source PublicationACS NANO
ISSN1936-0851
Volume13Issue:4Pages:4302
SubtypeArticle
AbstractGrape-seed extracts contain rich flavonoids with oligomeric proanthocyanidins (OPC). In this study, OPC containing hydrogel scaffolds can function as a natural photothermal agent for melanoma therapy and bioactive biomaterial for wound healing. Inspired by grape seed extracts, OPC were explored as a photothermal agent and endowed the hydrogel scaffolds with excellent and controlled photothermal ability. The theological property of the hydrogel scaffolds responded to irradiation time of near infrared (NIR) laser, and OPC contents. The compressive mechanical property of the hydrogel scaffolds was well modulated by NIR laser irradiation with different impact durations. The controlled high temperature induced by OPC-containing hydrogel scaffolds under NIR laser irradiation could effectively kill melanoma cells and suppress tumor growth. In addition, OPC-containing hydrogel scaffolds supported the proliferation and migration of human dermal fibroblasts and human umbilical vein endothelial cells, as well as obviously promoted angiogenesis and skin regeneration in both tumor-caused and chronic wounds. Therefore, OPC-containing hydrogel scaffolds possessed controlled photothermal, rheological, and compressive mechanical properties under NIR laser stimuli, as well as excellent biocompatibility and bioactivity for melanoma therapy and wound healing.
KeywordOPC-containing hydrogel scaffolds NIR laser responsive melanoma photothermal therapy skin wound healing
DOI10.1021/acsnano.8b09496
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:30[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27212
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Ma, Hongshi,Zhou, Quan,Chang, Jiang,et al. Grape Seed-Inspired Smart Hydrogel Scaffolds for Melanoma Therapy and Wound Healing[J]. ACS NANO,2019,13(4):4302.
APA Ma, Hongshi,Zhou, Quan,Chang, Jiang,&Wu, Chengtie.(2019).Grape Seed-Inspired Smart Hydrogel Scaffolds for Melanoma Therapy and Wound Healing.ACS NANO,13(4),4302.
MLA Ma, Hongshi,et al."Grape Seed-Inspired Smart Hydrogel Scaffolds for Melanoma Therapy and Wound Healing".ACS NANO 13.4(2019):4302.
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