Bioactive scaffolds for osteochondral regeneration
Deng, Cuijun; Chang, Jiang; Wu, Chengtie
AbstractTreatment for osteochondral defects remains a great challenge. Although several clinical strategies have been developed for management of osteochondral defects, the reconstruction of both cartilage and subchondral bone has proved to be difficult due to their different physiological structures and functions. Considering the restriction of cartilage to self-healing and the different biological properties in osteochondral tissue, new therapy strategies are essential to be developed. This review will focus on the latest developments of bioactive scaffolds, which facilitate the osteogenic and chondrogenic differentiation for the regeneration of bone and cartilage. Besides, the topic will also review the basic anatomy, strategies and challenges for osteochondral reconstruction, the selection of cells, biochemical factors and bioactive materials, as well as the design and preparation of bioactive scaffolds. Specifically, we summarize the most recent developments of single-type bioactive scaffolds for simultaneously regenerating cartilage and subchondral bone. Moreover, the future outlook of bioactive scaffolds in osteochondral tissue engineering will be discussed. This review offers a comprehensive summary of the most recent trend in osteochondral defect reconstruction, paving the way for the bioactive scaffolds in clinical therapy. The translational potential of this article: This review summaries the latest developments of single-type bioactive scaffolds for regeneration of osteochondral defects. We also highlight a new possible translational direction for cartilage formation by harnessing bioactive ions and propose novel paradigms for subchondral bone regeneration in application of bioceramic scaffolds. (C) 2018 The Authors. Published by Elsevier (Singapore) Pte Ltd on behalf of Chinese Speaking Orthopaedic Society.
KeywordBioactive scaffolds Bioceramics Cartilage repair Osteochondral regeneration Subchondral bone regeneration
WOS Research AreaOrthopedics
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Recommended Citation
GB/T 7714
Deng, Cuijun,Chang, Jiang,Wu, Chengtie. Bioactive scaffolds for osteochondral regeneration[J]. JOURNAL OF ORTHOPAEDIC TRANSLATION,2019,17:15.
APA Deng, Cuijun,Chang, Jiang,&Wu, Chengtie.(2019).Bioactive scaffolds for osteochondral regeneration.JOURNAL OF ORTHOPAEDIC TRANSLATION,17,15.
MLA Deng, Cuijun,et al."Bioactive scaffolds for osteochondral regeneration".JOURNAL OF ORTHOPAEDIC TRANSLATION 17(2019):15.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Deng, Cuijun]'s Articles
[Chang, Jiang]'s Articles
[Wu, Chengtie]'s Articles
Baidu academic
Similar articles in Baidu academic
[Deng, Cuijun]'s Articles
[Chang, Jiang]'s Articles
[Wu, Chengtie]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Deng, Cuijun]'s Articles
[Chang, Jiang]'s Articles
[Wu, Chengtie]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.