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Ultrasound/Acidity-Triggered and Nanoparticle-Enabled Analgesia
Gao, Xiong; Zhu, Piao; Yu, Luodan; Yang, Liqun; Chen, Yu
2019-05-01
Source PublicationADVANCED HEALTHCARE MATERIALS
ISSN2192-2640
Volume8Issue:9
SubtypeArticle
AbstractLocal anesthetics have been extensively employed to treat postoperative pain, but they generally suffer from short acting duration and potential neurotoxicity under high local concentrations, which require the controlled and sustained releasing patterns of treatment drugs. In this work, it is reported, for the first time, the construction of hollow mesoporous organosilica nanoparticles (HMONs)-based nanoplatforms for localized delivery and controlled/sustained release of loaded ropivacaine for local anesthetics, which can be repeatedly triggered by either external ultrasound irradiation or acidity triggering to release the payload, causing on-demand and long-lasting analgesia. Based on the in vivo mouse model of incision pain, the controlled and sustained release of ropivacaine achieves more than six hours of continuous analgesia, which is almost three times longer as compared to single free ropivacaine injection. The low neurotoxicity and high biocompatibility of HMONs for nanoparticle-enabled analgesia are also demonstrated both in vitro and in vivo. This designed/constructed HMONs-based nanoplatform provides a potential methodology for clinical pain management via on-demand and long-lasting pain relief.
Keyworddrug delivery mesoporous organosilica nanomedicine pain therapy stimuli-responsive nanoplatform
DOI10.1002/adhm.201801350
Language英语
WOS Research AreaEngineering ; Science & Technology - Other Topics ; Materials Science
PublisherWILEY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27132
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Gao, Xiong,Zhu, Piao,Yu, Luodan,et al. Ultrasound/Acidity-Triggered and Nanoparticle-Enabled Analgesia[J]. ADVANCED HEALTHCARE MATERIALS,2019,8(9).
APA Gao, Xiong,Zhu, Piao,Yu, Luodan,Yang, Liqun,&Chen, Yu.(2019).Ultrasound/Acidity-Triggered and Nanoparticle-Enabled Analgesia.ADVANCED HEALTHCARE MATERIALS,8(9).
MLA Gao, Xiong,et al."Ultrasound/Acidity-Triggered and Nanoparticle-Enabled Analgesia".ADVANCED HEALTHCARE MATERIALS 8.9(2019).
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