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Checkpoint blockade and nanosonosensitizer- augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice
Yue, Wenwen; Chen, Liang; Yu, Luodan; Zhou, Bangguo; Yin, Haohao; Ren, Weiwei; Liu, Chang; Guo, Lehang; Zhang, Yifeng; Sun, Liping; Zhang, Kun; Xu, Huixiong; Chen, Yu
2019-05-02
Source PublicationNATURE COMMUNICATIONS
ISSN2041-1723
Volume10
SubtypeArticle
AbstractCombined checkpoint blockade (e.g., PD1/PD-L1) with traditional clinical therapies can be hampered by side effects and low tumour-therapeutic outcome, hindering broad clinical translation. Here we report a combined tumour-therapeutic modality based on integrating nanosonosensitizers-augmented noninvasive sonodynamic therapy (SDT) with checkpoint-blockade immunotherapy. All components of the nanosonosensitizers (HMME/R837@Lip) are clinically approved, wherein liposomes act as carriers to co-encapsulate sonosensitizers (hematoporphyrin monomethyl ether (HMME)) and immune adjuvant (imiquimod (R837)). Using multiple tumour models, we demonstrate that combining nanosonosensitizers-augmented SDT with anti-PD-L1 induces an anti-tumour response, which not only arrests primary tumour progression, but also prevents lung metastasis. Furthermore, the combined treatment strategy offers a long-term immunological memory function, which can protect against tumour rechallenge after elimination of the initial tumours. Therefore, this work represents a proof-of-concept combinatorial tumour therapeutics based on noninvasive tumours-therapeutic modality with immunotherapy.
DOI10.1038/s41467-019-09760-3
Language英语
WOS Research AreaScience & Technology - Other Topics
PublisherNATURE PUBLISHING GROUP
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Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27126
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Yue, Wenwen,Chen, Liang,Yu, Luodan,et al. Checkpoint blockade and nanosonosensitizer- augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice[J]. NATURE COMMUNICATIONS,2019,10.
APA Yue, Wenwen.,Chen, Liang.,Yu, Luodan.,Zhou, Bangguo.,Yin, Haohao.,...&Chen, Yu.(2019).Checkpoint blockade and nanosonosensitizer- augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice.NATURE COMMUNICATIONS,10.
MLA Yue, Wenwen,et al."Checkpoint blockade and nanosonosensitizer- augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice".NATURE COMMUNICATIONS 10(2019).
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