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Enhanced tendon to bone healing in rotator cuff tear by PLLA/CPS composite films prepared by a simple melt-pressing method: An in vitro and in vivo study
Guo, Jingshu; Su, Wei; Jiang, Jia; Ning, Congqin; Zhao, Jinzhong; Liu, Xuanyong
2019-05-15
Source PublicationCOMPOSITES PART B-ENGINEERING
ISSN1359-8368
Volume165Pages:526
SubtypeArticle
AbstractHigh failure rate of tendon to bone healing after surgery has always been a challenging problem in rotator cuff repair. Considering the flexibility of PLLA and osteogenic activity of calcium phosphate silicate (CPS) ceramic, PLLA/CPS composite films were produced by a simple melt-pressing technique, the in vitro and in vivo biocompatibility and bioactivity were investigated. With an increase of CPS content, the adhesion and proliferation of cells on composite films were improved. The sample with a PLLA/CPS volume ratio of 5/1 (5P/C) showed a highest ALP activity expression. The in vivo results also revealed that the 5P/C composite sample had good biocompatibility and biodegradability, which could improve the organization of collagen and the formation of cartilage and bone. Moreover, the biomechanical test demonstrated that 5P/C group displayed the best mechanical performance among the three groups. 12 weeks after surgery, a well engineered tendon to bone interface was formed in the PLLA/CPS composite film case.
KeywordComposite film Melt-pressing technique Tendon to bone healing Rotator cuff tear
DOI10.1016/j.compositesb.2019.02.003
Language英语
WOS Research AreaEngineering ; Materials Science
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27115
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Guo, Jingshu,Su, Wei,Jiang, Jia,et al. Enhanced tendon to bone healing in rotator cuff tear by PLLA/CPS composite films prepared by a simple melt-pressing method: An in vitro and in vivo study[J]. COMPOSITES PART B-ENGINEERING,2019,165:526.
APA Guo, Jingshu,Su, Wei,Jiang, Jia,Ning, Congqin,Zhao, Jinzhong,&Liu, Xuanyong.(2019).Enhanced tendon to bone healing in rotator cuff tear by PLLA/CPS composite films prepared by a simple melt-pressing method: An in vitro and in vivo study.COMPOSITES PART B-ENGINEERING,165,526.
MLA Guo, Jingshu,et al."Enhanced tendon to bone healing in rotator cuff tear by PLLA/CPS composite films prepared by a simple melt-pressing method: An in vitro and in vivo study".COMPOSITES PART B-ENGINEERING 165(2019):526.
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