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Clearable Theranostic Platform with a pH-Independent Chemodynamic Therapy Enhancement Strategy for Synergetic Photothermal Tumor Therapy
Chen, Qian; Luo, Yu; Du, Wenxian; Liu, Zhuang; Zhang, Shengjian; Yang, Jiahui; Yao, Heliang; Liu, Tianzhi; Ma, Ming; Chen, Hangrong
2019-05-22
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume11Issue:20Pages:18133
SubtypeArticle
AbstractChemodynamic therapy (CDT) is an emerging field, which utilizes intratumoral iron-mediated Fenton chemistry for cancer therapy. However, the slightly acidic tumor environment is improper for the classical Fenton reaction, which is generally energetic in a narrow pH range (e.g., pH = 3-4). Herein, a kind of ultrasmall bovine serum albumin (BSA)-modified chalcopyrite nanoparticles (BSA-CuFeS2 NPs) was synthesized via a facile aqueous biomineralization strategy, which shows high dispersity and biocompatibility. Interestingly, the obtained BSA-CuFeS2 shows a pH-independent Fenton-like reaction, which could exert Fenton-like activity to efficiently generate (OH)-O-center dot under a weak acidic tumor environment. Combined with the extraordinarily high photothermal conversion (38.8%), BSA-CuFeS2 shows the synergistic function of high photothermal therapy (PTT) and enhanced CDT, that is, PTT/CDT. Importantly, such ultrasmall BSA-CuFeS2 NPs measuring around 4.9 nm can be quickly cleared out of the body through kidneys and liver, thus effectively avoiding long-term toxicity and systemic toxicity. Moreover, BSA-CuFeS2 NPs can act as an efficient T-2-weighted magnetic resonance imaging (MRI) contrast agent to guide tumor ablation in vivo. This work offers a universal approach to boost production (OH)-O-center dot by a pH-independent Fenton-like reaction strategy and achieves MRI-guided synergistic enhanced photothermal-CDT for highly efficient tumor treatment.
Keywordchemodynamic therapy photothermal therapy pH independent Fenton-like reaction clearance cancer theranostic
DOI10.1021/acsami.9b02905
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27107
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Chen, Qian,Luo, Yu,Du, Wenxian,et al. Clearable Theranostic Platform with a pH-Independent Chemodynamic Therapy Enhancement Strategy for Synergetic Photothermal Tumor Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(20):18133.
APA Chen, Qian.,Luo, Yu.,Du, Wenxian.,Liu, Zhuang.,Zhang, Shengjian.,...&Chen, Hangrong.(2019).Clearable Theranostic Platform with a pH-Independent Chemodynamic Therapy Enhancement Strategy for Synergetic Photothermal Tumor Therapy.ACS APPLIED MATERIALS & INTERFACES,11(20),18133.
MLA Chen, Qian,et al."Clearable Theranostic Platform with a pH-Independent Chemodynamic Therapy Enhancement Strategy for Synergetic Photothermal Tumor Therapy".ACS APPLIED MATERIALS & INTERFACES 11.20(2019):18133.
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