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Nanostructural Surfaces with Different Elastic Moduli Regulate the Immune Response by Stretching Macrophages
Chen, Lan; Wang, Donghui; Peng, Feng; Qiu, Jiajun; Ouyang, Liping; Qjao, Yuqin; Liu, Xuanyong
2019-06-01
Source PublicationNANO LETTERS
ISSN1530-6984
Volume19Issue:6Pages:3480
SubtypeArticle
AbstractA proper immune response is key for the successful implantation of biomaterials, and designing and fabricating biomaterials to regulate immune responses is the future trend. In this work, three different nanostructures were constructed on the surface of titanium using a hydrothermal method, and through a series of in vitro and in vivo experiments, we found that the aspect ratio of nanostructures can affect the elastic modulus of a material surface and further regulate immune cell behaviors. This work demonstrates that nanostructures with a higher aspect ratio can endow a material surface with a lower elastic modulus, which was confirmed by experiments and theoretical analyses. The deflection of nanostructures under the cell adsorption force is a substantial factor in stretching macrophages to enhance cell adhesion and spreading, further inducing macrophage polarization toward the M1 phenotype and leading to intense immune responses. In contrast, a nanostructure with a lower aspect ratio on a material surface leads to a higher surface elastic modulus, making deflection of the material difficult and creating a surface that is not conducive to macrophage adhesion and spreading, thus reducing the immune response. Moreover, molecular biology experiments indicated that regulation of the immune response by the elastic modulus is primarily related to the NF-kappa B signaling pathway. These findings suggest that the immune response can be regulated by constructing nanostructural surfaces with the proper elastic modulus through their influence on cell adhesion and spreading, which provides new insights into the surface design of biomaterials.
Keywordsurface elastic modulus macrophage polarization immune response implants molecular mechanism
DOI10.1021/acs.nanolett.9b00237
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27072
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Chen, Lan,Wang, Donghui,Peng, Feng,et al. Nanostructural Surfaces with Different Elastic Moduli Regulate the Immune Response by Stretching Macrophages[J]. NANO LETTERS,2019,19(6):3480.
APA Chen, Lan.,Wang, Donghui.,Peng, Feng.,Qiu, Jiajun.,Ouyang, Liping.,...&Liu, Xuanyong.(2019).Nanostructural Surfaces with Different Elastic Moduli Regulate the Immune Response by Stretching Macrophages.NANO LETTERS,19(6),3480.
MLA Chen, Lan,et al."Nanostructural Surfaces with Different Elastic Moduli Regulate the Immune Response by Stretching Macrophages".NANO LETTERS 19.6(2019):3480.
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