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Highly Catalytic Niobium Carbide (MXene) Promotes Hematopoietic Recovery after Radiation by Free Radical Scavenging
Ren, Xiangyi; Huo, Minfeng; Wang, Mengmeng; Lin, Han; Zhang, Xuxia; Yin, Jun; Chen, Yu; Chen, Honghong
2019-06-01
Source PublicationACS NANO
ISSN1936-0851
Volume13Issue:6Pages:6438
SubtypeArticle
AbstractIonizing radiation (IR) has been extensively used in industry and radiotherapy, but IR exposure from nuclear or radiological accidents often causes serious health effects in an exposed individual, and its application in radiotherapy inevitably brings undesirable damage to normal tissues. In this work, we have developed ultrathin two-dimensional (2D) niobium carbide (Nb2C) MXene as a radioprotectant and explored its application in scavenging free radicals against IR. The 2D Nb2C MXene features intriguing antioxidant properties in effectively eliminating hydrogen peroxide (H2O2), hydroxyl radicals ((OH)-O-center dot), and superoxide radicals (O-2(center dot-)). Pretreatment with biocompatible polyvinylpyrrolidone (PVP)-functionalized Nb2C nanosheets (Nb2C-PVP NSs) significantly reduces IR-induced production of reactive oxygen species (ROS), resulting in enhanced cell viability in vitro. A single intravenous injection of Nb2C-PVP significantly enhances the survival rate of 5 and 6.5 Gy irradiated mice to 100% and 81.25%, respectively, and significantly increases bone marrow mononuclear cells after IR. Critically, Nb2C-PVP reverses the damage of the hematopoietic system in irradiated mice. Single administration of Nb2C-PVP significantly increases superoxide dismutase (SOD) activities, decreases malondialdehyde levels, and thereby reduces IR-induced pathological damage in the testis, small intestine, lung, and liver of 5 Gy irradiated mice. Importantly, Nb2C-PVP is almost completely eliminated from the mouse body on day 14 post treatment, and no obvious toxicities are observed during the 30-day post treatment period. Our study pioneers the application of 2D MXenes with intrinsic radioprotective nature in vivo.
KeywordNb2C MXenes radiation protection free radical scavenger superoxide dismutase hematopoiesis
DOI10.1021/acsnano.8b09327
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27070
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Ren, Xiangyi,Huo, Minfeng,Wang, Mengmeng,et al. Highly Catalytic Niobium Carbide (MXene) Promotes Hematopoietic Recovery after Radiation by Free Radical Scavenging[J]. ACS NANO,2019,13(6):6438.
APA Ren, Xiangyi.,Huo, Minfeng.,Wang, Mengmeng.,Lin, Han.,Zhang, Xuxia.,...&Chen, Honghong.(2019).Highly Catalytic Niobium Carbide (MXene) Promotes Hematopoietic Recovery after Radiation by Free Radical Scavenging.ACS NANO,13(6),6438.
MLA Ren, Xiangyi,et al."Highly Catalytic Niobium Carbide (MXene) Promotes Hematopoietic Recovery after Radiation by Free Radical Scavenging".ACS NANO 13.6(2019):6438.
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